Lupus Mouse
Invented by Prof Fiona Watt from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
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Info
| Catalogue Number | 151518 |
| Antigen/Gene or Protein Targets | Interferon-g (IFNg) |
| Disease Keywords | Systemic Lupus Erythematosus (SLE); autoimmune disease |
| Relevance | Disease model for systemic lupus erythematosus; in vivo study of IFNg expression in skin |
| Production Details | An involucrin-interferon transgene expression construct was injected into fertilised oocytes from F1 hybrid CBA/C57BL/10 mice. Transgene-positive mice were mated to C57BL/10 mice to generate founder lines. |
| Conditional | Yes |
| Growth/Phenotype Keywords | Skin abnormalities (hair follicle, epidermis); immune abnormalities (contact hypersensitivity, autoantibody production, nephritis) |
| Mouse Genetic Background/Cross History | CBA/C57BL/1 |
| Zygosity | Heterozygous |
| Research Area | Genetic Studies Tools, Immunology |
| Notes |
The Inv-IFNg mouse presents a phenotype analogous to systemic lupus erythematosus, and is an ideal tool for study of the disease in vivo. Inv-IFNg mice demonstrate key features of the lupus pathology: Skin abnormalities; - retarded hair growth, hypopigmentation of hair - extreme age-related erythema (reddening of skin) - flaky and pustular skin lesions, particularly around joints and appendages Developmental abnormalities; - growth retardation - hunched appearance, odd gait - enlarged spleens, shrunken thymus Immune abnormalities; - contact hypersensitivity - autoantibody production, nephritis |
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