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Lupus Mouse


Catalogue Number 151518
Antigen/Gene or Protein Targets Interferon-g (IFNg)
Disease Keywords Systemic Lupus Erythematosus (SLE); autoimmune disease
Relevance Disease model for systemic lupus erythematosus; in vivo study of IFNg expression in skin
Production Details An involucrin-interferon transgene expression construct was injected into fertilised oocytes from F1 hybrid CBA/C57BL/10 mice. Transgene-positive mice were mated to C57BL/10 mice to generate founder lines.
Conditional Yes
Growth/Phenotype Keywords Skin abnormalities (hair follicle, epidermis); immune abnormalities (contact hypersensitivity, autoantibody production, nephritis)
Mouse Genetic Background/Cross History CBA/C57BL/1
Zygosity Heterozygous
Research Area Genetic Studies Tools, Immunology
Notes The Inv-IFNg mouse presents a phenotype analogous to systemic lupus erythematosus, and is an ideal tool for study of the disease in vivo.

Inv-IFNg mice demonstrate key features of the lupus pathology:

Skin abnormalities;

- retarded hair growth, hypopigmentation of hair

- extreme age-related erythema (reddening of skin)

- flaky and pustular skin lesions, particularly around joints and appendages

Developmental abnormalities;

- growth retardation

- hunched appearance, odd gait

- enlarged spleens, shrunken thymus

Immune abnormalities;

- contact hypersensitivity

- autoantibody production, nephritis

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