Anti-LewisA [PR 5C5]
Invented by Prof Walter Bodmer from University of Oxford
Invented at University of Oxford
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151501 |
| Applications | ELISA IHC |
| Antigen/Gene or Protein Targets | Lewis A antigen |
| Reactivity | Human |
| Relevance | Lewis a antigen is expressed on colonic mucus, epithelial cells and cell membranes. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens. PR 5C5 is useful for histological diagnosis of colon disorders and has wide reactivity with bowel, small intestine, stomach and colo-rectal tumours. |
| Host | Mouse |
| Immunogen | Mucosal scrapings and membrane preparations from normal colorectal epithelium and possibly booster inoculations with the colon carcinoma cell line HT29. |
| Subclass | IgG1 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | Recommended for use with formalin fixed tissues. |
| Research Area | Cardiovascular, Immunology |
References: 2 entries
Richman et al. 1987. Int J Cancer. 39(3):317-28. PMID: 2434440.
IHC
Monoclonal antibodies to human colorectal epithelium: markers for differentiation and tumour characterization.
Europe PMC ID: 2434440
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References: 2 entries
Richman et al. 1987. Int J Cancer. 39(3):317-28. PMID: 2434440.
IHC
Monoclonal antibodies to human colorectal epithelium: markers for differentiation and tumour characterization.
Add a reference
