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Anti-LewisA [PR 5C5]


Catalogue Number 151501
Applications ELISA IHC
Antigen/Gene or Protein Targets Lewis A antigen
Reactivity Human
Relevance Lewis a antigen is expressed on colonic mucus, epithelial cells and cell membranes. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens. PR 5C5 is useful for histological diagnosis of colon disorders and has wide reactivity with bowel, small intestine, stomach and colo-rectal tumours.
Host Mouse
Immunogen Mucosal scrapings and membrane preparations from normal colorectal epithelium and possibly booster inoculations with the colon carcinoma cell line HT29.
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Recommended for use with formalin fixed tissues.
Research Area Cardiovascular, Immunology

References: 1 entry

Richman et al. 1987. Int J Cancer. 39(3):317-28. PMID: 2434440.


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