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Anti-EBNA2 [PE2]

Invented by Prof Martin Rowe at University Of Birmingham

Info

Catalogue Number 151472
Applications IHC IF IP WB ChIP-seq
Antigen/Gene or Protein Targets Epstein Barr Virus Encoded Nuclear Antigen 2 (EBNA2)
Reactivity Human and Virus
Relevance The Epstein-Barr Virus (EBV), also called Human herpesvirus 4 (HHV-4), is a virus of the herpes family and is one of the most common viruses in humans. EBNA2 is one of the few genes of Epstein-Barr virus which are necessary for immortalization of human primary B lymphocytes. The EBNA2 protein acts as a transcriptional activator of several viral and cellular genes.
Host Mouse
Immunogen Recombinant fusion protein against EBNA2The immunogen was a beta-gal fusion protein from plasmid pKH-2A10 that contains aa 341-480 of B95.8 type EBNA2A (Fig 4 in Young et al 1989)
Subclass IgG1
Positive Control Immunohistochemistry (Acetone fixed): EBV positive Raji cell Line. Western blotting: B95-8 cell
Molecular Weight (kDa) 52
Myeloma Used P3X63Ag8.653
Research Area Immunology, Virology

References: 22 entries

David et al. 2017. Haematologica. :. PMID: 28232371.

WB

c-Myc dysregulation is a co-transforming event for nuclear factor-κB activated B cells.

Europe PMC ID: 28232371

Wille et al. 2016. J Virol. :. PMID: 28003489.

WB

Restricted TET2 Expression in Germinal Center Type B Cells Promotes Stringent Epstein-Barr Virus Latency.

Europe PMC ID: 28003489

Wang et al. 2015. J Virol. :. PMID: 26719268.

WB ChIP-seq

Epstein-Barr Virus Nuclear Antigen 3 (EBNA3) Proteins Regulate EBNA2 Binding to Distinct RBPJ Genomic Sites.

Europe PMC ID: 26719268

Pujals et al. 2015. Autophagy. :. PMID: 26565591.

IHC WB

Constitutive autophagy contributes to resistance to TP53-mediated apoptosis in Epstein-Barr virus-positive latency III B-cell lymphoproliferations.

Europe PMC ID: 26565591

Gibson et al. 2011. Am J Surg Pathol. 35(6):807-15. PMID: 21552113.

EBV-positive extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the posttransplant setting: a distinct type of posttransplant lymphoproliferative disorder?

Europe PMC ID: 21552113

Boshoff et al. 1998. Blood. 91(5):1671-9. PMID: 9473233.

Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice.

Europe PMC ID: 9473233

Brink et al. 1997. J Clin Pathol. 50(11):911-8. PMID: 9462239.

IHC WB

Presence of Epstein-Barr virus latency type III at the single cell level in post-transplantation lymphoproliferative disorders and AIDS related lymphomas.

Europe PMC ID: 9462239

Niedobitek et al. 1995. Blood. 86(2):659-65. PMID: 7605996.

IHC

Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma.

Europe PMC ID: 7605996

Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.

Europe PMC ID: 1845872

Rowe et al. 1991. J Exp Med. 173(1):147-58. PMID: 1845872.

IF

Young et al. 1989. N Engl J Med. 321(16):1080-5. PMID: 2552313.

Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease.

Europe PMC ID: 2552313

Young et al. 1988. J Gen Virol. 69 ( Pt 5):1051-65. PMID: 2836550.

Epstein-Barr virus gene expression in nasopharyngeal carcinoma.

Europe PMC ID: 2836550


Add a reference

References: 22 entries

David et al. 2017. Haematologica. :. PMID: 28232371.

WB

c-Myc dysregulation is a co-transforming event for nuclear factor-κB activated B cells.

Europe PMC ID: 28232371

Wille et al. 2016. J Virol. :. PMID: 28003489.

WB

Restricted TET2 Expression in Germinal Center Type B Cells Promotes Stringent Epstein-Barr Virus Latency.

Europe PMC ID: 28003489

Wang et al. 2015. J Virol. :. PMID: 26719268.

WB ChIP-seq

Epstein-Barr Virus Nuclear Antigen 3 (EBNA3) Proteins Regulate EBNA2 Binding to Distinct RBPJ Genomic Sites.

Europe PMC ID: 26719268

Pujals et al. 2015. Autophagy. :. PMID: 26565591.

IHC WB

Constitutive autophagy contributes to resistance to TP53-mediated apoptosis in Epstein-Barr virus-positive latency III B-cell lymphoproliferations.

Europe PMC ID: 26565591

Gibson et al. 2011. Am J Surg Pathol. 35(6):807-15. PMID: 21552113.

EBV-positive extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the posttransplant setting: a distinct type of posttransplant lymphoproliferative disorder?

Europe PMC ID: 21552113

Boshoff et al. 1998. Blood. 91(5):1671-9. PMID: 9473233.

Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice.

Europe PMC ID: 9473233

Brink et al. 1997. J Clin Pathol. 50(11):911-8. PMID: 9462239.

IHC WB

Presence of Epstein-Barr virus latency type III at the single cell level in post-transplantation lymphoproliferative disorders and AIDS related lymphomas.

Europe PMC ID: 9462239

Niedobitek et al. 1995. Blood. 86(2):659-65. PMID: 7605996.

IHC

Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma.

Europe PMC ID: 7605996

Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.

Europe PMC ID: 1845872

Rowe et al. 1991. J Exp Med. 173(1):147-58. PMID: 1845872.

IF

Young et al. 1989. N Engl J Med. 321(16):1080-5. PMID: 2552313.

Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease.

Europe PMC ID: 2552313

Young et al. 1988. J Gen Virol. 69 ( Pt 5):1051-65. PMID: 2836550.

Epstein-Barr virus gene expression in nasopharyngeal carcinoma.

Europe PMC ID: 2836550


Add a reference

References: 22 entries

David et al. 2017. Haematologica. :. PMID: 28232371.

WB

c-Myc dysregulation is a co-transforming event for nuclear factor-κB activated B cells.

Wille et al. 2016. J Virol. :. PMID: 28003489.

WB

Restricted TET2 Expression in Germinal Center Type B Cells Promotes Stringent Epstein-Barr Virus Latency.

Wang et al. 2015. J Virol. :. PMID: 26719268.

WB ChIP-seq

Epstein-Barr Virus Nuclear Antigen 3 (EBNA3) Proteins Regulate EBNA2 Binding to Distinct RBPJ Genomic Sites.

Pujals et al. 2015. Autophagy. :. PMID: 26565591.

IHC WB

Constitutive autophagy contributes to resistance to TP53-mediated apoptosis in Epstein-Barr virus-positive latency III B-cell lymphoproliferations.

Gibson et al. 2011. Am J Surg Pathol. 35(6):807-15. PMID: 21552113.

EBV-positive extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the posttransplant setting: a distinct type of posttransplant lymphoproliferative disorder?

Boshoff et al. 1998. Blood. 91(5):1671-9. PMID: 9473233.

Establishing a KSHV+ cell line (BCP-1) from peripheral blood and characterizing its growth in Nod/SCID mice.

Brink et al. 1997. J Clin Pathol. 50(11):911-8. PMID: 9462239.

IHC WB

Presence of Epstein-Barr virus latency type III at the single cell level in post-transplantation lymphoproliferative disorders and AIDS related lymphomas.

Niedobitek et al. 1995. Blood. 86(2):659-65. PMID: 7605996.

IHC

Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma.

Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.

Rowe et al. 1991. J Exp Med. 173(1):147-58. PMID: 1845872.

IF

Young et al. 1989. N Engl J Med. 321(16):1080-5. PMID: 2552313.

Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease.

Young et al. 1988. J Gen Virol. 69 ( Pt 5):1051-65. PMID: 2836550.

Epstein-Barr virus gene expression in nasopharyngeal carcinoma.


Add a reference


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