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Anti-MCM5 [A2.12A7.C10.D9.D10]

Info

Catalogue Number 151469
Applications IF WB
Antigen/Gene or Protein Targets Mini Chromosome Maintenance protein5 (MCM5)
Synonyms Minichromosome Maintenance Complex Component 5; P1-CDC46; CDC46; Minichromosome Maintenance Deficient 5 (Cell Division Cycle 46); EC 3.6.4.12
Reactivity Human
Relevance MCM5 (Mini Chromosome Maintainance protein-5) is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. MCM5 is a member of the MCM family of chromatin-binding proteins, which have DNA dependent ATPase motifs in their central domain. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may have a role in cell cycle regulation. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. It has been reported that immunocytochemical assessment of MCM5 expression may be used as a diagnostic tool for cervical cancer and urothelial neoplasia. MCM5 expression may also be applicable in the detection of a number of other cancers including bladder, lung and oesophageal.
Host Mouse
Immunogen Bacterially expressed His-tagged human Mcm5 (amino acids 367-582)
Subclass IgG2b
Positive Control HeLa, HL60
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions 20% OPI serum
Strain Balb/c
Notes Also known as: 352.12A7 or A2.12A7.C10.D9.D10.
Research Area Epigenetics & Nuclear Signalling

References: 1 entry

Stoeber et al. 2002. J Natl Cancer Inst. 94(14):1071-9. PMID: 12122098.


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