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Anti-CD17a [HM47]


Catalogue Number 151468
Applications IHC IP WB
Antigen/Gene or Protein Targets CD79a
Synonyms LAMPA; CD17a; LGP12; Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; CD17 antigen-like family member A; LAMP1
Reactivity Bovine, Chicken, Horse, Human, Guinea Pig, Mouse, Opossum, Pig, Primate, Rat and Rabbit
Relevance The B cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a / mb1 and CD79b / B29 polypeptides, non covalently associated with membrane bound immunoglobulins on B cells. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B cell lymphomas, in B cell lines, the majority of acute leukemias of precursor B cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling. CD79a is widely used as an adjunct to CD20 for detecting normal and neoplastic B cells in tissues sections.
Host Mouse
Immunogen Synthetic peptide of 14 amino acids representing amino acids 202-216 of the human mb-1 cDNA sequence
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT. Ultroser G (**) can be used at 1% if the cells are not growing well.
Research Area Adhesion, Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References: 4 entries

Lankester et al. 1994. J Immunol. 152(5):2157-62. PMID: 8133032.

Brouns et al. 1993. Eur J Immunol. 23(5):1088-97. PMID: 8477803.

Mason et al. 1991. J Immunol. 147(11):2474-82. PMID: 1747162.

van Noesel et al. 1991. J Immunol. 146(11):3881-8. PMID: 2033258.

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