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|Antigen/Gene or Protein Targets||p23|
|Relevance||In vivo study of p23 knockout, golgi apparatus and early secretory pathway function|
|Production Details||A p23 targeting vector, constructed from genomic fragments, but replacing exon 1 of the p23 gene with a resistance marker, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, and injected into C57BL/6 blastocysts. Chimeric offspring were mated to C57BL/6 mice to generate mice heterozygous for the p23 knockout allele, p23+/- mice.|
|Growth/Phenotype Keywords||Golgi apparatus abnormalities|
|Research Area||Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Genetic Studies Tools, Immunology|
Genetic Bkg: 129/C57BL/6.
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