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p23+/- Mouse


Catalogue Number 151467
Antigen/Gene or Protein Targets p23
Relevance In vivo study of p23 knockout, golgi apparatus and early secretory pathway function
Production Details A p23 targeting vector, constructed from genomic fragments, but replacing exon 1 of the p23 gene with a resistance marker, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, and injected into C57BL/6 blastocysts. Chimeric offspring were mated to C57BL/6 mice to generate mice heterozygous for the p23 knockout allele, p23+/- mice.
Growth/Phenotype Keywords Golgi apparatus abnormalities
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Genetic Studies Tools, Immunology
Notes Genetic Bkg: 129/C57BL/6.

Zygosity: Heterozygous

References: 1 entry

Denzel et al. 2000. Curr Biol. 10(1):55-8. PMID: 10660306.

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