Anti-FBW7 [FBOX 3a9/1]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (4)
- Inventor Info
Info
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| Catalogue Number | 151461 |
| Applications | FACS IHC IF IP WB |
| Antigen/Gene or Protein Targets | F-box/WD repeat-containing protein 7 (FBW7, Cdc4) |
| Synonyms | F-Box And WD Repeat Domain Containing 7; F-Box Protein FBX30; SEL-10; Fbx30; HCdc4; FBW7; Hago; Homolog Of C Elegans Sel-10; F-Box Protein SEL-10; Archipelago Homolog; F-Box Protein FBW7; Archipelago; FBXO30; FBXW6; CDC4; FBW6; AGO |
| Reactivity | Human and Mouse |
| Relevance | SCF (Skp, Cullin, F-box containing complex) ubiquitin ligases regulate the degradation of many proteins involved in the control of cell division and growth. F-box proteins are the SCF components that bind to substrates, and this binding is usually signaled by substrate phosphorylation. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E, and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 thus negatively regulates several key oncoproteins. Accordingly, FBW7 is a tumor suppressor that is mutated in a wide spectrum of human cancers, and FBW7 functions as a haplo-insufficient tumor suppressor in mice. |
| Host | Mouse |
| Immunogen | Synthetic peptide of human sequence |
| Subclass | IgG1 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | E4 + 5% FCS |
| Research Area | Cancer, Protein Degradation |
References: 4 entries
Tu et al. 2013. PLoS One. 8(7):e68574. PMID: 23840897.
Recombinant human adenovirus-p53 injection induced apoptosis in hepatocellular carcinoma cell lines mediated by p53-Fbxw7 pathway, which controls c-Myc and cyclin E.
Europe PMC ID: 23840897
Nateri et al. 2004. Science. 303(5662):1374-8. PMID: 14739463.
The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling.
Europe PMC ID: 14739463
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References: 4 entries
Tu et al. 2013. PLoS One. 8(7):e68574. PMID: 23840897.
Recombinant human adenovirus-p53 injection induced apoptosis in hepatocellular carcinoma cell lines mediated by p53-Fbxw7 pathway, which controls c-Myc and cyclin E.
Nateri et al. 2004. Science. 303(5662):1374-8. PMID: 14739463.
The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling.
Add a reference
