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JIM1 Cell Line


Catalogue Number 151449
Host Human
Tissue Blood
Disease Keywords Human multiple myeloma, cancer
Model Tumour line
Relevance JIM1 was established from plasma myeloma cells derived from pleural fluid of an advanced multiple myeloma patient, and is homoplastic with the cell line JIM3. It allows in vitro study and comparison of genetic instability in myeloma tumour lines and in vitro study of the effects of DNA repair deficiency in myeloma tumour lines. JIM1 shows typical plasma cell phenotype (CD38, PCA-1 8A and CD24 positive), deficient in DNA repair.
Production Details Derived from plasma myeloma cells from pleural fluid of advanced multiple myeloma female patient.
Research Area Cancer, DNA Damage and Repair, Drug Discovery & Development
Growth/Phenotype Keywords Suspension
Recommended Growing Conditions Dexter culture medium, consisting of Fischer's medium + 20% FCS +10-7 M hydrocortisone sodium succinate. Seed at 2-9 x 10 5 cells/cm3 5% CO2; 37°C
Notes STR profiling showed that this cell line is of female origin
Cellosaurus ID CVCL_2532

References: 4 entries

Brito et al. 2009. Haematologica. 94(1):78-86. PMID: 19059936.

Leone et al. 2008. Clin Cancer Res. 14(19):6033-41. PMID: 18829482.

Velangi et al. 2004. Carcinogenesis. 25(10):1795-803. PMID: 15142887.

Hamilton et al. 1991. Leukemia. 5(9):768-71. PMID: 1943229.

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