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Catalogue Number 151445
Parental Line MTSV1-7
Host Human
Tissue Breast
Disease Keywords Normal
Model Immortalised Line
Relevance The 1-7HB2 cell line is a clonal derivative of the human mammary luminal epithelial cell line MTSV1-7 identified by screening for branching morphology. It is a potent tool for in vitro study of branching morphogenesis of human mammary epithelial cells and the role of integrins in mammary morphogenesis. MTSV1-7 is a clonal non-tumourigenic cell line developed by immortalizing luminal epithelial cells cultured from milk using the SV40 T antigen. The cell line forms branching structures in the presence of fibroblast cultures or fibroblast-conditioned medium and forms spheroids in collagen type I gels.
Research Area Cell Structure and Motility, Structural Biology
Growth/Phenotype Keywords Morphology, adhesion properties
Recommended Growing Conditions DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + Hydrocortisone (5 µg/ml) + Bovine Insulin (10 µg/ml).
Cellosaurus ID CVCL_2261

References: 2 entries

Bartek et al. 1991. Proc Natl Acad Sci U S A. 88(9):3520-4. PMID: 1708884.

Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus.

Europe PMC ID: 1708884


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References: 2 entries

Bartek et al. 1991. Proc Natl Acad Sci U S A. 88(9):3520-4. PMID: 1708884.

Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus.

Europe PMC ID: 1708884


Add a reference

References: 2 entries

Bartek et al. 1991. Proc Natl Acad Sci U S A. 88(9):3520-4. PMID: 1708884.

Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus.


Add a reference


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