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GSTP1GSTP2 KO Mouse

Invented by Prof Roland Wolf at University of Dundee, Dr Colin Henderson at University of Dundee

Info

Catalogue Number 151443
Antigen/Gene or Protein Targets Glutathione Transferase P1 and P2 (GSTP1, GSTP2)
Disease Keywords Cancer; lung adenoma; drug metabolism & toxicity
Relevance In vivo study of GSTP1/2 (regulator of protein synthesis/degradation) knockout in tumourigenesis, drug metabolism and toxicity; disease model for drug metabolism and toxicity; tumourigenesis model (skin, lung) (chemically induced)
Production Details A Gstp1/2 targeting vector, replacing all of the Gstp1 gene and exons 6 and 7 of the Gstp2 gene with a resistance cassette, was transfected into E14Tg2a.IV ES cells. Properly targeted ES cells containing a homologous recombination event were selected, cloned, and injected into blastocysts. Chimeric mice were mated with MF1 mice to generate mice heterozygous for GSTP1/2 knockout. Heterozygous mice were interbred to generate mice homozygous for GSTP1/2 knockout.
Conditional No
Growth/Phenotype Keywords Tumourigenesis (lung, skin); drug metabolism; drug toxicity
Mouse Genetic Background/Cross History Available on both 129/C57BL/6 and C57BL6
Zygosity Homozygous
Research Area Cancer, DNA Damage and Repair, Genetic Studies Tools

References: 8 entries

Zhou et al. 2008. Am J Respir Crit Care Med. 178(12):1202-10. PMID: 18787219.

Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.

Europe PMC ID: 18787219

Elsby et al. 2003. J Biol Chem. 278(25):22243-9. PMID: 12646564.

Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.

Europe PMC ID: 12646564

Rosario et al. 2000. Mol Pharmacol. 58(1):167-74. PMID: 10860939.

Cellular response to a glutathione S-transferase P1-1 activated prodrug.

Europe PMC ID: 10860939

Henderson et al. 1998. Proc Natl Acad Sci U S A. 95(9):5275-80. PMID: 9560266.

Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.

Europe PMC ID: 9560266


Add a reference

References: 8 entries

Zhou et al. 2008. Am J Respir Crit Care Med. 178(12):1202-10. PMID: 18787219.

Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.

Europe PMC ID: 18787219

Elsby et al. 2003. J Biol Chem. 278(25):22243-9. PMID: 12646564.

Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.

Europe PMC ID: 12646564

Rosario et al. 2000. Mol Pharmacol. 58(1):167-74. PMID: 10860939.

Cellular response to a glutathione S-transferase P1-1 activated prodrug.

Europe PMC ID: 10860939

Henderson et al. 1998. Proc Natl Acad Sci U S A. 95(9):5275-80. PMID: 9560266.

Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.

Europe PMC ID: 9560266


Add a reference

References: 8 entries

Zhou et al. 2008. Am J Respir Crit Care Med. 178(12):1202-10. PMID: 18787219.

Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.

Elsby et al. 2003. J Biol Chem. 278(25):22243-9. PMID: 12646564.

Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.

Rosario et al. 2000. Mol Pharmacol. 58(1):167-74. PMID: 10860939.

Cellular response to a glutathione S-transferase P1-1 activated prodrug.

Henderson et al. 1998. Proc Natl Acad Sci U S A. 95(9):5275-80. PMID: 9560266.

Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.


Add a reference


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