Anti-Integrin a4 [BU49]
Invented at University Of Birmingham
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151439 |
| Applications | FACS IP |
| Antigen/Gene or Protein Targets | Integrin alpha 4 (CD49d) |
| Synonyms | Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR |
| Reactivity | Human |
| Relevance | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 4 (CD49d) is a 150 kDa protein characterised by a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain. Hetrodimers are formed with integrin beta 1 and 7. BU49 induces phosphorylation of a cAMP response element-binding protein (CREB) in the human monocyte-like cell line, U937. |
| Host | Mouse |
| Immunogen | Hicett myeloma cell line |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 150 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS |
| Research Area | Adhesion, Cardiovascular, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology |
References: 4 entries
Ikewaki et al. 2002. Microbiol Immunol. 46(10):685-95. PMID: 12477247.
A very late activating antigen-alpha4 (CD49d) monoclonal antibody, BU49 induces phosphorylation of a cAMP response element-binding protein (CREB), resulting in induction of homotypic cell aggregation and enhancement of interleukin-8 (IL-8) production.
Europe PMC ID: 12477247
Nojima et al. 1992. J Exp Med. 175(4):1045-53. PMID: 1372641.
Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein.
Europe PMC ID: 1372641
Add a reference
References: 4 entries
Ikewaki et al. 2002. Microbiol Immunol. 46(10):685-95. PMID: 12477247.
A very late activating antigen-alpha4 (CD49d) monoclonal antibody, BU49 induces phosphorylation of a cAMP response element-binding protein (CREB), resulting in induction of homotypic cell aggregation and enhancement of interleukin-8 (IL-8) production.
Nojima et al. 1992. J Exp Med. 175(4):1045-53. PMID: 1372641.
Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein.
Add a reference
