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Anti-Integrin a4 [BU49]


Catalogue Number 151439
Applications FACS IP
Antigen/Gene or Protein Targets Integrin alpha 4 (CD49d)
Synonyms Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 4 (CD49d) is a 150 kDa protein characterised by a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain. Hetrodimers are formed with integrin beta 1 and 7. BU49 induces phosphorylation of a cAMP response element-binding protein (CREB) in the human monocyte-like cell line, U937.
Host Mouse
Immunogen Hicett myeloma cell line
Subclass IgG1
Molecular Weight (kDa) 150
Recommended Growing Conditions RPMI 1640 + 10% FCS
Research Area Adhesion, Cardiovascular, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References: 2 entries

Ikewaki et al. 2002. Microbiol Immunol. 46(10):685-95. PMID: 12477247.

Nojima et al. 1992. J Exp Med. 175(4):1045-53. PMID: 1372641.

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