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Anti-Integrin aX [BU15]

Info

Catalogue Number 151435
Applications FACS IHC IF IP
Antigen/Gene or Protein Targets Integrin alpha X (CD11C)
Reactivity Human, Primate and Dog
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha X is found on hairy cell leukaemias, malignant histiocytes, on tissue macrophages, monocytes, activated neutrophils and some T-cell clones. BU15 has utility for the diagnosis of hairy cell leukaemia.
Host Mouse
Immunogen Dendritic cells of synovial fluid
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS
Strain Balb/c
Research Area Adhesion, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References: 19 entries

McMichael AJ et al. (Ed) 1997. Leucocyte Typing III. ISBN 13 9780192615527

Myou et al. 2002. Immunology. 107(1):77-85. PMID: 12225365.

Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2.

Europe PMC ID: 12225365

Rezzonico et al. 2001. Blood. 97(10):2932-40. PMID: 11342414.

Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.

Europe PMC ID: 11342414

Yoshino et al. 2000. Exp Anim. 49(2):97-110. PMID: 10889948.

Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies.

Europe PMC ID: 10889948

Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568.

Prolonged phenotypic, functional, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand.

Europe PMC ID: 9763568

Van der Vieren et al. 1995. Immunity. 3(6):683-90. PMID: 8777714.

A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3.

Europe PMC ID: 8777714

Stewart et al. 1994. Methods Cell Biol. 41:39-60. PMID: 7861972.

Cell preparation for the identification of leukocytes.

Europe PMC ID: 7861972

Trowald-Wigh et al. 1993. Vet Immunol Immunopathol. 38(3-4):297-310. PMID: 8291207.

Canine neutrophil adhesion proteins and Fc-receptors in healthy dogs and dogs with adhesion protein deficiency, as studied by flow cytometry.

Europe PMC ID: 8291207

Larson et al. 1990. Immunol Rev. 114:181-217. PMID: 2196220.

Structure and function of leukocyte integrins.

Europe PMC ID: 2196220

Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.

The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.

Europe PMC ID: 3456894


Add a reference

References: 19 entries

McMichael AJ et al. (Ed) 1997. Leucocyte Typing III. ISBN 13 9780192615527

Myou et al. 2002. Immunology. 107(1):77-85. PMID: 12225365.

Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2.

Europe PMC ID: 12225365

Rezzonico et al. 2001. Blood. 97(10):2932-40. PMID: 11342414.

Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.

Europe PMC ID: 11342414

Yoshino et al. 2000. Exp Anim. 49(2):97-110. PMID: 10889948.

Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies.

Europe PMC ID: 10889948

Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568.

Prolonged phenotypic, functional, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand.

Europe PMC ID: 9763568

Van der Vieren et al. 1995. Immunity. 3(6):683-90. PMID: 8777714.

A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3.

Europe PMC ID: 8777714

Stewart et al. 1994. Methods Cell Biol. 41:39-60. PMID: 7861972.

Cell preparation for the identification of leukocytes.

Europe PMC ID: 7861972

Trowald-Wigh et al. 1993. Vet Immunol Immunopathol. 38(3-4):297-310. PMID: 8291207.

Canine neutrophil adhesion proteins and Fc-receptors in healthy dogs and dogs with adhesion protein deficiency, as studied by flow cytometry.

Europe PMC ID: 8291207

Larson et al. 1990. Immunol Rev. 114:181-217. PMID: 2196220.

Structure and function of leukocyte integrins.

Europe PMC ID: 2196220

Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.

The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.

Europe PMC ID: 3456894


Add a reference

References: 19 entries

McMichael AJ et al. (Ed) 1997. Leucocyte Typing III. ISBN 13 9780192615527

Myou et al. 2002. Immunology. 107(1):77-85. PMID: 12225365.

Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2.

Rezzonico et al. 2001. Blood. 97(10):2932-40. PMID: 11342414.

Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB.

Yoshino et al. 2000. Exp Anim. 49(2):97-110. PMID: 10889948.

Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies.

Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568.

Prolonged phenotypic, functional, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand.

Van der Vieren et al. 1995. Immunity. 3(6):683-90. PMID: 8777714.

A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3.

Stewart et al. 1994. Methods Cell Biol. 41:39-60. PMID: 7861972.

Cell preparation for the identification of leukocytes.

Trowald-Wigh et al. 1993. Vet Immunol Immunopathol. 38(3-4):297-310. PMID: 8291207.

Canine neutrophil adhesion proteins and Fc-receptors in healthy dogs and dogs with adhesion protein deficiency, as studied by flow cytometry.

Larson et al. 1990. Immunol Rev. 114:181-217. PMID: 2196220.

Structure and function of leukocyte integrins.

Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.

The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules.


Add a reference


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