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Anti-Integrin aX [BU15]

Info

Catalogue Number 151435
Applications FACS IHC IF IP
Antigen/Gene or Protein Targets Integrin alpha X (CD11C)
Reactivity Human, Primate and Dog
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha X is found on hairy cell leukaemias, malignant histiocytes, on tissue macrophages, monocytes, activated neutrophils and some T-cell clones. BU15 has utility for the diagnosis of hairy cell leukaemia.
Host Mouse
Immunogen Dendritic cells of synovial fluid
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS
Strain Balb/c
Research Area Adhesion, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References: 10 entries

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Yoshino et al. 2000. Exp Anim. 49(2):97-110. PMID: 10889948.

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Stewart et al. 1994. Methods Cell Biol. 41:39-60. PMID: 7861972.

Trowald-Wigh et al. 1993. Vet Immunol Immunopathol. 38(3-4):297-310. PMID: 8291207.

Larson et al. 1990. Immunol Rev. 114:181-217. PMID: 2196220.

Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894.


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