Anti-CR2 [BU33]
Invented at University Of Birmingham
- Datasheet
- References (10)
- Inventor Info
Info
| Catalogue Number | 151432 |
| Applications | FACS IHC IP WB |
| Antigen/Gene or Protein Targets | Complement component (3d/Epstein Barr virus) receptor 2 (CR2, CD21) |
| Synonyms | Complement Component 3d Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor; EBV Receptor; C3DR; CD21 Antigen; CVID7; SLEB9; CD21; Cr2; CR |
| Reactivity | Human |
| Relevance | CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CR2 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CR2 expression is also gradually lost after stimulation of B cells in vitro. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. CR2 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B-cell activation. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, CR2 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders. |
| Host | Mouse |
| Immunogen | HF B1 plasmactyoid cell line, considered to be "late B like" |
| Subclass | IgG1 |
| Myeloma Used | NS0 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS |
| Strain | Balb/c |
| Notes | FCM 1/50 to 1/200 |
| Research Area | Cell Signaling & Signal Transduction, Immunology |
References: 10 entries
Mayall et al. 2001. J Comp Pathol. 124(1):83-7. PMID: 11428193.
The anti-human CD21 antibody, BU33, identifies equine B cells.
Europe PMC ID: 11428193
Scholssman SF. et al. 1995. Leucocyte Typing V. Oxford University Press. ISBN-13: 978-0192623768
Henchoz et al. 1994. Immunology. 81(2):285-90. PMID: 7512529.
Stimulation of human IgE production by a subset of anti-CD21 monoclonal antibodies: requirement of a co-signal to modulate epsilon transcripts.
Europe PMC ID: 7512529
Bacon et al. 1993. Eur J Immunol. 23(10):2721-4. PMID: 7691616.
CD21 expressed on basophilic cells is involved in histamine release triggered by CD23 and anti-CD21 antibodies.
Europe PMC ID: 7691616
Aubry et al. 1992. Nature. 358(6386):505-7. PMID: 1386409.
CD21 is a ligand for CD23 and regulates IgE production.
Europe PMC ID: 1386409
Leucocyte Typing IV, 1989. Oxford University Press. ISBN-13: 978-0192618672
Add a reference
References: 10 entries
Mayall et al. 2001. J Comp Pathol. 124(1):83-7. PMID: 11428193.
The anti-human CD21 antibody, BU33, identifies equine B cells.
Scholssman SF. et al. 1995. Leucocyte Typing V. Oxford University Press. ISBN-13: 978-0192623768
Henchoz et al. 1994. Immunology. 81(2):285-90. PMID: 7512529.
Stimulation of human IgE production by a subset of anti-CD21 monoclonal antibodies: requirement of a co-signal to modulate epsilon transcripts.
Bacon et al. 1993. Eur J Immunol. 23(10):2721-4. PMID: 7691616.
CD21 expressed on basophilic cells is involved in histamine release triggered by CD23 and anti-CD21 antibodies.
Aubry et al. 1992. Nature. 358(6386):505-7. PMID: 1386409.
CD21 is a ligand for CD23 and regulates IgE production.
Leucocyte Typing IV, 1989. Oxford University Press. ISBN-13: 978-0192618672
Add a reference
