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|Applications||FACS IHC IP WB|
|Antigen/Gene or Protein Targets||Complement component (3d/Epstein Barr virus) receptor 2 (CR2, CD21)|
|Synonyms||Complement Component 3d Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor; EBV Receptor; C3DR; CD21 Antigen; CVID7; SLEB9; CD21; Cr2; CR|
|Relevance||CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CR2 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CR2 expression is also gradually lost after stimulation of B cells in vitro. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. CR2 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B-cell activation. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, CR2 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders.|
|Immunogen||HF B1 plasmactyoid cell line, considered to be "late B like"|
|Recommended Growing Conditions||RPMI 1640 + 10% FCS|
|Notes||FCM 1/50 to 1/200|
|Research Area||Cell Signaling & Signal Transduction, Immunology|
References: 6 entries
Mayall et al. 2001. J Comp Pathol. 124(1):83-7. PMID: 11428193.
Scholssman SF. et al. 1995. Leucocyte Typing V. Oxford University Press. ISBN-13: 978-0192623768
Henchoz et al. 1994. Immunology. 81(2):285-90. PMID: 7512529.
Bacon et al. 1993. Eur J Immunol. 23(10):2721-4. PMID: 7691616.
Aubry et al. 1992. Nature. 358(6386):505-7. PMID: 1386409.
Leucocyte Typing IV, 1989. Oxford University Press. ISBN-13: 978-0192618672
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