Anti-CD21 [BU32]
Invented at University Of Birmingham
- Datasheet
- References (9)
- Inventor Info
Info
| Catalogue Number | 151431 |
| Applications | FACS IHC IF WB |
| Antigen/Gene or Protein Targets | Complement component (3d/Epstein Barr virus) receptor 2 (CR2, CD21) |
| Synonyms | Complement Component 3d Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor; EBV Receptor; C3DR; CD21 Antigen; CVID7; SLEB9; CD21; Cr2; CR |
| Reactivity | Human |
| Relevance | CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CR2 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CR2 expression is also gradually lost after stimulation of B cells in vitro. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. CR2 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B-cell activation. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, CR2 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders. |
| Host | Mouse |
| Immunogen | Myeloma cell line Rob |
| Subclass | IgG1 |
| Myeloma Used | NS0 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS |
| Strain | Balb/c |
| Research Area | Cell Signaling & Signal Transduction, Immunology |
References: 9 entries
Knapp, W. et al. eds. 1989. Leucocyte Typing IV Oxford University Press. ISBN-13: 978-0192618672
Leucocyte Typing III 1987. ISBN-13: 978-0192615527
Leucocyte Typing V 1995. ISBN-13: 978-0192623768
Leucocyte Typing VI 1998. Garland Publishing NY. ISBN-13: 978-0815327455
Ling, NR., Brown, B., Immunobiology (1992) 185(2-4) pp403-14
Jackson et al. 2020. BMC Genet. 21(1):101. PMID: 32907542.
WB
Herishanu et al. 2013. J Immunol. 190(2):784-93. PMID: 23241880.
Masilamani et al. 2004. Rheumatology (Oxford). 43(2):186-90. PMID: 12867574.
Aubry et al. 1992. Nature. 358(6386):505-7. PMID: 1386409.
Add a reference
References: 9 entries
Knapp, W. et al. eds. 1989. Leucocyte Typing IV Oxford University Press. ISBN-13: 978-0192618672
Leucocyte Typing III 1987. ISBN-13: 978-0192615527
Leucocyte Typing V 1995. ISBN-13: 978-0192623768
Leucocyte Typing VI 1998. Garland Publishing NY. ISBN-13: 978-0815327455
Ling, NR., Brown, B., Immunobiology (1992) 185(2-4) pp403-14
Jackson et al. 2020. BMC Genet. 21(1):101. PMID: 32907542.
WB
Herishanu et al. 2013. J Immunol. 190(2):784-93. PMID: 23241880.
Masilamani et al. 2004. Rheumatology (Oxford). 43(2):186-90. PMID: 12867574.
Aubry et al. 1992. Nature. 358(6386):505-7. PMID: 1386409.
Add a reference
