- References (3)
- Inventor Info
|Antigen/Gene or Protein Targets||Large neutral Amino acid Transporter 1 (LAT1, CD98)|
|Synonyms||Solute Carrier Family 7 Member 5; L-Type Amino Acid Transporter; Integral Membrane Protein E16; CD98 Light Chain; 4F2 Light Chain; MPE16; HLAT1; LAT1; Sodium-Independent Neutral Amino Acid Transporter LAT1; Large Neutral Amino Acids Transporter 1; D16S469E; CD98LC; CD98; E16|
Monoclonal antibody directed against LAT1 transporter channel protein and can aid investigation into amino acid transporter channel upregulation, a common mutation in oncogenesis.
Background and Research Application
LAT1, also known as SLC7A5, is part of the APC superfamily and forms a heterodimeric amino acid transporter channel. LAT1 interacts with CD98 glycoprotein via a conserved disulphide. This transporter channel is involved in the uptake of essential amino acids in various regions, particularly the placenta and blood brain barrier.
LAT1 expressed on numerous cell types including B cells, activated T cells, monocytes, granulocytes, erythrocytes and endothelial cells. LAT1 is up-regulated on leucocytes in inflammatory lesions and is strongly expressed by neoplastic cells. Changes in amino acid transporter expression, including LAT1, are thought to be an early change in oncogenesis, as they provide growth and survival advantages.
|Immunogen||Plasma cell line 8226|
|Immunogen UniProt ID||Q01650|
|Recommended Growing Conditions||RPMI 1640 + 10% FCS|
Purified using multi-step affinity chromatography with protein A.
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.
Points of Interest
Anti-LAT1 was able to induce weak homotypic aggregation of U937 cells.
1mg/ml as standard
|Research Area||Cancer, Cell Signaling & Signal Transduction, Metabolism|
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