Anti-MCM5 [A2.7A3.F12.A7]
Invented at University of Cambridge
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151418 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | Mini Chromosome Maintenance protein5 (MCM5) |
| Reactivity | Human |
| Relevance | Mini Chromosome Maintenance protein-5 (MCM5) is a component of the prereplicative complex that is essential for DNA replication. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. MCM5 expression may be applicable in the detection of a number of cancers including cervical, bladder, lung and oesophageal. |
| Host | Mouse |
| Immunogen | His-tagged human Mcm5 (amino acids 367–582) |
| Subclass | IgG2b |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes | Clone is also referred to CRCT5.1. |
| Research Area | Epigenetics & Nuclear Signalling |
References: 4 entries
Rakotomalala et al. 2008. J Biol Chem. 283(42):28729-40. PMID: 18693245.
Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy.
Europe PMC ID: 18693245
Williams et al. 1998. Proc Natl Acad Sci U S A. 95(25):14932-7. PMID: 9843993.
Improved cervical smear assessment using antibodies against proteins that regulate DNA replication.
Europe PMC ID: 9843993
Add a reference
References: 4 entries
Rakotomalala et al. 2008. J Biol Chem. 283(42):28729-40. PMID: 18693245.
Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy.
Williams et al. 1998. Proc Natl Acad Sci U S A. 95(25):14932-7. PMID: 9843993.
Improved cervical smear assessment using antibodies against proteins that regulate DNA replication.
Add a reference
