Anti-BCL2 [bcl-2/90]
Invented by Dr Jacqueline Cordell from University of Oxford
Invented at University of Oxford
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Info
| Catalogue Number | 151408 |
| Applications | IHC WB |
| Antigen/Gene or Protein Targets | Bcl2 |
| Reactivity | Human |
| Relevance | The pro-survival protein BCL2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause of schizophrenia and autoimmunity. It is also a cause of resistance to cancer treatments. |
| Host | Mouse |
| Immunogen | Synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein |
| Subclass | IgG1 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Signaling & Signal Transduction, Metabolism |
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