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Anti-Integrin aEb7 [BP6]


Catalogue Number 151379
Applications IHC IP
Antigen/Gene or Protein Targets Integrin alpha E/ß7 (CD103)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha E/beta7 (aE/b7) is a heterodimer comprising a 150kDa alpha E chain and a 120kDa beta 7 chain. The expression of Integrin aE/b7 defines a developmentally important subset of T cells, namely mucosal T cells including all intraepithelial lymphocytes and ~20% of lamina propria T cells. Integrin aE/b7 is also a selective marker for intestinal intra-epithelial T-cells. BP6 may be used in the diagnosis of enteropathy-associated lymphoma and hairy cell leukaemia.
Host Mouse
Immunogen Hairy cell spleen lysate
Subclass IgG1 kappa
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Notes Ultroser G can be used at 1% if the cells are not growing well.
Research Area Adhesion

References: 1 entry

Micklem et al. 1991. Am J Pathol. 139(6):1297-301. PMID: 1750505.

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