Anti-Integrin aEb7 [BP6]
Invented by Karen Pulford from University of Oxford
Invented at University of Oxford
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151379 |
| Applications | IHC IP |
| Antigen/Gene or Protein Targets | Integrin alpha E/ß7 (CD103) |
| Reactivity | Human |
| Relevance | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha E/beta7 (aE/b7) is a heterodimer comprising a 150kDa alpha E chain and a 120kDa beta 7 chain. The expression of Integrin aE/b7 defines a developmentally important subset of T cells, namely mucosal T cells including all intraepithelial lymphocytes and ~20% of lamina propria T cells. Integrin aE/b7 is also a selective marker for intestinal intra-epithelial T-cells. BP6 may be used in the diagnosis of enteropathy-associated lymphoma and hairy cell leukaemia. |
| Host | Mouse |
| Immunogen | Hairy cell spleen lysate |
| Subclass | IgG1 kappa |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Notes | Ultroser G can be used at 1% if the cells are not growing well. |
| Research Area | Adhesion |
References: 2 entries
Micklem et al. 1991. Am J Pathol. 139(6):1297-301. PMID: 1750505.
HML-1 antigen on mucosa-associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta 7 subunit.
Europe PMC ID: 1750505
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References: 2 entries
Micklem et al. 1991. Am J Pathol. 139(6):1297-301. PMID: 1750505.
HML-1 antigen on mucosa-associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta 7 subunit.
Add a reference
