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Anti-LILR [GHI/75]

Invented by Karen Pulford at University of Oxford

Info

Catalogue Number 151377
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets Leukocyte Immunogolobulin-like Receptor 1 (LILR, CD85)
Reactivity Human
Relevance LILR is a 120kD membrane glycoprotein expressed strongly on plasma cells, moderately on circulating B cells and weakly on monocytes. It is not expressed on neutrophils, T cells, NK cells or any non-hematopoietic cells.
Host Mouse
Immunogen Hairy cell leukaemia cells
Subclass IgG2b
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Notes Ultroser G can be used at 1% if the cells are not growing well.
Research Area Immunology

References: 8 entries

Morel et al. 2008. J Immunol. 181(4):2368-81. PMID: 18684926.

HLA class I molecules regulate IFN-gamma production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j.

Europe PMC ID: 18684926

Kirwan et al. 2005. J Immunol. 175(8):5006-15. PMID: 16210603.

Killer cell Ig-like receptor-dependent signaling by Ig-like transcript 2 (ILT2/CD85j/LILRB1/LIR-1).

Europe PMC ID: 16210603

Banham et al. 1999. J Leukoc Biol. 65(6):841-5. PMID: 10380908.

Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily.

Europe PMC ID: 10380908

Pulford et al. 1991. Clin Exp Immunol. 85(3):429-35. PMID: 1893623.

A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasms.

Europe PMC ID: 1893623


Add a reference

References: 8 entries

Morel et al. 2008. J Immunol. 181(4):2368-81. PMID: 18684926.

HLA class I molecules regulate IFN-gamma production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j.

Europe PMC ID: 18684926

Kirwan et al. 2005. J Immunol. 175(8):5006-15. PMID: 16210603.

Killer cell Ig-like receptor-dependent signaling by Ig-like transcript 2 (ILT2/CD85j/LILRB1/LIR-1).

Europe PMC ID: 16210603

Banham et al. 1999. J Leukoc Biol. 65(6):841-5. PMID: 10380908.

Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily.

Europe PMC ID: 10380908

Pulford et al. 1991. Clin Exp Immunol. 85(3):429-35. PMID: 1893623.

A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasms.

Europe PMC ID: 1893623


Add a reference

References: 8 entries

Morel et al. 2008. J Immunol. 181(4):2368-81. PMID: 18684926.

HLA class I molecules regulate IFN-gamma production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j.

Kirwan et al. 2005. J Immunol. 175(8):5006-15. PMID: 16210603.

Killer cell Ig-like receptor-dependent signaling by Ig-like transcript 2 (ILT2/CD85j/LILRB1/LIR-1).

Banham et al. 1999. J Leukoc Biol. 65(6):841-5. PMID: 10380908.

Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily.

Pulford et al. 1991. Clin Exp Immunol. 85(3):429-35. PMID: 1893623.

A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasms.


Add a reference


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