Anti-CD45RA [4KB5]
Invented by Karen Pulford from University of Oxford
Invented at University of Oxford
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 151362 |
| Applications | FACS IHC IP WB |
| Antigen/Gene or Protein Targets | Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45RA) |
| Synonyms | Protein Tyrosine Phosphatase; Receptor Type C; CD45 Antigen; CD45; L-CA; T200; Protein Tyrosine Phosphatase; Receptor Type; C Polypeptide; T200 Leukocyte Common Antigen; T200 Glycoprotein; EC 3.1.3.48; GP180; CD45R; B220; LCA; LY5 |
| Reactivity | Human |
| Relevance | PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45RA is an isoform of the PTPRC (CD45) protein which is selectively expressed on B cells. |
| Host | Mouse |
| Immunogen | B cell lymphoma |
| Subclass | IgG1 kappa |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Notes |
Ultroser G can be used at 1% if the cells are not growing well. Immunohistochemistry (Paraffin) (IHC (P)) |
| Research Area | Cell Type or Organelle Marker, Immunology, Stem Cell Biology |
References: 3 entries
Pulford KAF et al. 1987. In: McMichael A, et al (eds) Leucocyte Typing III. Oxford University Press, Oxford, New York and Tokyo, p 828
Li et al. 2005. Blood. 105(8):3295-302. PMID: 15626731.
A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma.
Europe PMC ID: 15626731
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References: 3 entries
Pulford KAF et al. 1987. In: McMichael A, et al (eds) Leucocyte Typing III. Oxford University Press, Oxford, New York and Tokyo, p 828
Li et al. 2005. Blood. 105(8):3295-302. PMID: 15626731.
A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma.
Add a reference
