Anti-PTPRC [2B11]
Invented by Karen Pulford from University of Oxford
Invented at University of Oxford
- Datasheet
- References (10)
- Inventor Info
Info
| Catalogue Number | 151361 |
| Applications | FACS IHC WB |
| Antigen/Gene or Protein Targets | Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45) |
| Synonyms | Protein Tyrosine Phosphatase; Receptor Type C; CD45; L-CA; T200; Protein Tyrosine Phosphatase; Receptor Type; C Polypeptide; T200 Leukocyte Common Antigen; Leukocyte Common Antigen; T200 Glycoprotein; GP180; CD45R; B220; LCA; LY5 |
| Reactivity | Human |
| Relevance | PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). 2B11 is widely used, in conjunction with the CD45RB antibody PD7/26, to detect white cell-derived tumours in paraffin sections. |
| Host | Mouse |
| Immunogen | T cell Lymphoma cells |
| Subclass | IgG1 kappa |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Notes | Ultroser G can be used at 1% if the cells are not growing well. |
| Research Area | Cardiovascular, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Neurobiology, Stem Cell Biology |
References: 10 entries
Chijiwa et al. 2015. Int J Oncol. :. PMID: 25963555.
IHC
Tsuneki et al. 2015. Lab Invest. :. PMID: 25961170.
IHC
A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway.
Europe PMC ID: 25961170
Establishment of patient-derived cancer xenografts in immunodeficient NOG mice.
Europe PMC ID: 25963555
Gatter et al. 1984. Am J Clin Pathol. 82(1):33-43. PMID: 6741874.
The differential diagnosis of routinely processed anaplastic tumors using monoclonal antibodies.
Europe PMC ID: 6741874
Warnke et al. 1983. N Engl J Med. 309(21):1275-81. PMID: 6355845.
Diagnosis of human lymphoma with monoclonal antileukocyte antibodies.
Europe PMC ID: 6355845
Gatter et al. 1983. J Biol Response Mod. 2(4):369-95. PMID: 6196454.
Monoclonal antibodies in diagnostic pathology: techniques and applications.
Europe PMC ID: 6196454
Add a reference
References: 10 entries
Chijiwa et al. 2015. Int J Oncol. :. PMID: 25963555.
IHC
Tsuneki et al. 2015. Lab Invest. :. PMID: 25961170.
IHC
A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway.
Establishment of patient-derived cancer xenografts in immunodeficient NOG mice.
Gatter et al. 1984. Am J Clin Pathol. 82(1):33-43. PMID: 6741874.
The differential diagnosis of routinely processed anaplastic tumors using monoclonal antibodies.
Warnke et al. 1983. N Engl J Med. 309(21):1275-81. PMID: 6355845.
Diagnosis of human lymphoma with monoclonal antileukocyte antibodies.
Gatter et al. 1983. J Biol Response Mod. 2(4):369-95. PMID: 6196454.
Monoclonal antibodies in diagnostic pathology: techniques and applications.
Add a reference
