Anti-SIGLEC2 [TPD44/D11]
Invented by Karen Pulford from University of Oxford
Invented at University of Oxford
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Info
| Catalogue Number | 151356 |
| Applications | FACS IHC |
| Antigen/Gene or Protein Targets | Sialic acid binding Ig-like lectin 2 (SIGLEC2, CD22, BL-CAM) |
| Synonyms | CD22 Antigen; Sialic Acid Binding Ig-Like Lectin 2; B-Lymphocyte Cell Adhesion Molecule; T-Cell Surface Antigen Leu-14; SIGLEC-2; BL-CAM |
| Reactivity | Human |
| Relevance | SIGLEC-2 (CD22) is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC-2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC-2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC-2 is strongly expressed in hairy cell leukaemias. |
| Host | Mouse |
| Immunogen | B cell lymphoma cells |
| Subclass | IgG2a |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Notes | Ultroser G can be used at 1% if the cells are not growing well. |
| Research Area | Cancer, Immunology, Stem Cell Biology |
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