Anti-CD21L [R4/23]
Invented by Dr Jacqueline Cordell from University of Oxford
Invented at University of Oxford
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 151355 |
| Applications | IHC WB |
| Antigen/Gene or Protein Targets | Complement component (3d/Epstein Barr virus) receptor 2; long form (CR2, CD21L) |
| Synonyms | Complement Component (3d/Epstein Barr Virus) Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor 3; EBV Receptor 3; C3DR 3; CD21 Antigen; CVID7; SLEB9; CD21; Cr2 |
| Reactivity | Human |
| Relevance | CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. Follicular dendritic cells (contained in B cell follicles) selectively express the “Long” isoform of CR2 (CD21L) that contains an additional exon (10a) compared to CR2 (CD21). R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues. |
| Host | Mouse |
| Immunogen | Cell lysate from a chronic lymphocytic leukemia patient. |
| Subclass | IgM |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Notes | Ultroser G can be used at 1% if the cells are not growing well. |
| Research Area | Cell Type or Organelle Marker, Immunology |
References: 8 entries
Nakamura et al. 1999. Am J Surg Pathol. 23(4):363-76. PMID: 10199466.
Hodgkin's disease expressing follicular dendritic cell marker CD21 without any other B-cell marker: a clinicopathologic study of nine cases.
Europe PMC ID: 10199466
Heinen et al. 1984. Eur J Immunol. 14(3):267-73. PMID: 6368249.
Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization.
Europe PMC ID: 6368249
Naiem et al. 1983. J Clin Pathol. 36(2):167-75. PMID: 6338047.
Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue.
Europe PMC ID: 6338047
Stein et al. 1982. Int J Cancer. 30(4):445-59. PMID: 6754630.
Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.
Europe PMC ID: 6754630
Add a reference
References: 8 entries
Nakamura et al. 1999. Am J Surg Pathol. 23(4):363-76. PMID: 10199466.
Hodgkin's disease expressing follicular dendritic cell marker CD21 without any other B-cell marker: a clinicopathologic study of nine cases.
Heinen et al. 1984. Eur J Immunol. 14(3):267-73. PMID: 6368249.
Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization.
Naiem et al. 1983. J Clin Pathol. 36(2):167-75. PMID: 6338047.
Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue.
Stein et al. 1982. Int J Cancer. 30(4):445-59. PMID: 6754630.
Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.
Add a reference
