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Anti-CD21L [R4/23]

Invented by Dr Jacqueline Cordell at University of Oxford

Info

Catalogue Number 151355
Applications IHC WB
Antigen/Gene or Protein Targets Complement component (3d/Epstein Barr virus) receptor 2; long form (CR2, CD21L)
Synonyms Complement Component (3d/Epstein Barr Virus) Receptor 2; Epstein-Barr Virus Receptor 2; Complement C3d Receptor 3; EBV Receptor 3; C3DR 3; CD21 Antigen; CVID7; SLEB9; CD21; Cr2
Reactivity Human
Relevance CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. Follicular dendritic cells (contained in B cell follicles) selectively express the “Long” isoform of CR2 (CD21L) that contains an additional exon (10a) compared to CR2 (CD21). R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues.
Host Mouse
Immunogen Cell lysate from a chronic lymphocytic leukemia patient.
Subclass IgM
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Notes Ultroser G can be used at 1% if the cells are not growing well.
Research Area Cell Type or Organelle Marker, Immunology

References: 8 entries

Nakamura et al. 1999. Am J Surg Pathol. 23(4):363-76. PMID: 10199466.

Hodgkin's disease expressing follicular dendritic cell marker CD21 without any other B-cell marker: a clinicopathologic study of nine cases.

Europe PMC ID: 10199466

Heinen et al. 1984. Eur J Immunol. 14(3):267-73. PMID: 6368249.

Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization.

Europe PMC ID: 6368249

Naiem et al. 1983. J Clin Pathol. 36(2):167-75. PMID: 6338047.

Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue.

Europe PMC ID: 6338047

Stein et al. 1982. Int J Cancer. 30(4):445-59. PMID: 6754630.

Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.

Europe PMC ID: 6754630


Add a reference

References: 8 entries

Nakamura et al. 1999. Am J Surg Pathol. 23(4):363-76. PMID: 10199466.

Hodgkin's disease expressing follicular dendritic cell marker CD21 without any other B-cell marker: a clinicopathologic study of nine cases.

Europe PMC ID: 10199466

Heinen et al. 1984. Eur J Immunol. 14(3):267-73. PMID: 6368249.

Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization.

Europe PMC ID: 6368249

Naiem et al. 1983. J Clin Pathol. 36(2):167-75. PMID: 6338047.

Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue.

Europe PMC ID: 6338047

Stein et al. 1982. Int J Cancer. 30(4):445-59. PMID: 6754630.

Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.

Europe PMC ID: 6754630


Add a reference

References: 8 entries

Nakamura et al. 1999. Am J Surg Pathol. 23(4):363-76. PMID: 10199466.

Hodgkin's disease expressing follicular dendritic cell marker CD21 without any other B-cell marker: a clinicopathologic study of nine cases.

Heinen et al. 1984. Eur J Immunol. 14(3):267-73. PMID: 6368249.

Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization.

Naiem et al. 1983. J Clin Pathol. 36(2):167-75. PMID: 6338047.

Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue.

Stein et al. 1982. Int J Cancer. 30(4):445-59. PMID: 6754630.

Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.


Add a reference


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