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Anti-Leu2 [X107]


Catalogue Number 151346
Applications FACS IHC
Antigen/Gene or Protein Targets Leu2 (CD8)
Synonyms CD8a Molecule; T-Lymphocyte Differentiation Antigen T8/Leu-2; CD8 Antigen; Alpha Polypeptide (P32); MAL; T-Cell Surface Glycoprotein CD8 Alpha Chain; Leu2 T-Lymphocyte Antigen; OKT8 T-Cell Antigen; T-Cell Antigen Leu2; T8 T-Cell Antigen; CD8a Antigen; Leu2; P32
Reactivity Human
Relevance Leu-2 (CD8) is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. Leu-2 is present on human suppressor / cytotoxic T cells which make up 30% of circulating T cells. X107 may be used to detect these cells in tissue sections and also their neoplastic counterparts.
Host Mouse
Immunogen Synthetic peptide ( the 13 c-terminal residues of the cytoplasmic domain of human CD8a)
Subclass Not Known
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Notes Ultroser G can be used at 1% if the cells are not growing well.
Research Area Immunology, Stem Cell Biology

References: 1 entry

Knapp W. et al. 1989. Leukocyte Typing IV. Oxford University Press. p 1076. ISBN-13: 978-0192618672

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