Anti-Leu2 [C8/144B]
Invented by Dr Jacqueline Cordell from University of Oxford
Invented at University of Oxford
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 151345 |
| Applications | IHC IF IP WB |
| Antigen/Gene or Protein Targets | Leu2 (CD8) |
| Synonyms | CD8a Molecule; T-Lymphocyte Differentiation Antigen T8/Leu-2; CD8 Antigen; Alpha Polypeptide (P32); MAL; T-Cell Surface Glycoprotein CD8 Alpha Chain; Leu2 T-Lymphocyte Antigen; OKT8 T-Cell Antigen; T-Cell Antigen Leu2; T8 T-Cell Antigen; CD8a Antigen; Leu2; P32 |
| Reactivity | Human |
| Relevance | CD8 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. CD8 is present on human suppressor/cytotoxic T cells which make up 30% of circulating T cells. C8/144B can be used to detect these cells in tissue sections and also their neoplastic counterparts. |
| Host | Mouse |
| Immunogen | Synthetic peptide (the 13 C-terminal residues of the cytoplasmic domain of human CD8a) |
| Subclass | IgG1 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) |
| Notes | Ultroser G can be used at 1% if the cells are not growing well. |
| Research Area | Immunology, Stem Cell Biology |
References: 8 entries
van Gool et al. 2015. Clin Cancer Res. 21(14):3347-55. PMID: 25878334.
IF
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer.
Europe PMC ID: 25878334
Harlin et al. 2009. Cancer Res. 69(7):3077-85. PMID: 19293190.
Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment.
Europe PMC ID: 19293190
Sato et al. 2005. Proc Natl Acad Sci U S A. 102(51):18538-43. PMID: 16344461.
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.
Europe PMC ID: 16344461
Mason et al. 1992. J Clin Pathol. 45(12):1084-8. PMID: 1479035.
Immunohistological detection of human cytotoxic/suppressor T cells using antibodies to a CD8 peptide sequence.
Europe PMC ID: 1479035
Add a reference
References: 8 entries
van Gool et al. 2015. Clin Cancer Res. 21(14):3347-55. PMID: 25878334.
IF
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer.
Harlin et al. 2009. Cancer Res. 69(7):3077-85. PMID: 19293190.
Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment.
Sato et al. 2005. Proc Natl Acad Sci U S A. 102(51):18538-43. PMID: 16344461.
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.
Mason et al. 1992. J Clin Pathol. 45(12):1084-8. PMID: 1479035.
Immunohistological detection of human cytotoxic/suppressor T cells using antibodies to a CD8 peptide sequence.
Add a reference
