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Anti-CD3 [PC3/188A]


Catalogue Number 151342
Applications IHC WB
Antigen/Gene or Protein Targets CD3
Synonyms T3 complex
Reactivity Bovine, Chicken, Horse, Guinea Pig, Opossum, Pig, Primate, Rat and Rabbit
Relevance The CD3 complex, composed of five CD3 polypeptide chains, associates with the T cell antigen receptor (TCR) and is found on all mature human T lymphocytes. CD3 can be used for the identification of normal and malignant T lymphocytes in paraffin embedded or frozen tissue sections. PC3/188A also detects CD3 in mammalian tissues.
Host Mouse
Immunogen Peptide sequence (156-168) from the intracytoplasmic portion of the epsilon-chain of CD3
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM)
Notes Ultroser G can be used at 1% if the cells are not growing well.
Research Area Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References: 4 entries

Doursout et al. 2013. J Interferon Cytokine Res. 33(7):376-83. PMID: 23600861.

Wang et al. 2012. PLoS One. 7(7):e39525. PMID: 22848356.

Bianchi et al. 2012. Diabetes Metab Res Rev. 28(2):156-63. PMID: 21922635.

Jones et al. 1993. J Immunol. 150(12):5429-35. PMID: 8515069.

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