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Anti-CD2 [X53 (X/3)]


Catalogue Number 151341
Applications FACS IHC
Antigen/Gene or Protein Targets CD2
Synonyms CD2 Molecule; CD2 Antigen (P50); Sheep Red Blood Cell Receptor; T-Cell Surface Antigen T11/Leu-5; Erythrocyte Receptor; Rosette Receptor; LFA-3 Receptor
Reactivity Human
Relevance T-cell surface antigen CD2 is an antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3/ CD58) and CD48/BCM1 to mediate adhesion between T cells and other cell types. Intracellularly, it interacts with lck. CD2 can be used for monitoring T-cell number in periperal blood, and identification of lymphomas and leukaemias of T-cell origin.
Host Mouse
Immunogen T cell lymphoma cells
Subclass IgG1 kappa
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT
Notes Ultroser G can be used at 1% if the cells are not growing well.
Research Area Adhesion, Cancer, Cell Type or Organelle Marker, Immunology, Stem Cell Biology

References: 2 entries

CD guide for CD2 (1989) Leukocyte Typing IV, Oxford University Press, Oxford, New York and Tokyo; p1074-1075

Pawelec G et al. 1989. Stimulatory capacity of Workship T-cell antibodies on T-lymphocyte clones. Leukocyte Typing IV, Oxford Univeristy Press, Oxford, New York and Tokyo; p310-311.2.

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