Cat. #151341
Anti-CD2 [X53 (X/3)]
Cat. #: 151341
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: CD2
Class: Monoclonal
Application: FACS ; IHC
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Karen Pulford
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-CD2 [X53 (X/3)]
- Alternate name: CD2 Molecule; CD2 Antigen (P5); Sheep Red Blood Cell Receptor; T-Cell Surface Antigen T11/Leu-5; Erythrocyte Receptor; Rosette Receptor; LFA-3 Receptor
- Clone: X53 (X/3)
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IHC
- Description: T-cell surface antigen CD2 is an antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3/ CD58) and CD48/BCM1 to mediate adhesion between T cells and other cell types. Intracellularly, it interacts with lck. CD2 can be used for monitoring T-cell number in periperal blood, and identification of lymphomas and leukaemias of T-cell origin.
- Immunogen: T cell lymphoma cells
- Isotype: IgG1 kappa
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: CD2
- Target background: T-cell surface antigen CD2 is an antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3/ CD58) and CD48/BCM1 to mediate adhesion between T cells and other cell types. Intracellularly, it interacts with lck. CD2 can be used for monitoring T-cell number in periperal blood, and identification of lymphomas and leukaemias of T-cell origin.
Applications
- Application: FACS ; IHC
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- CD guide for CD2 (1989) Leukocyte Typing IV, Oxford University Press, Oxford, New York and Tokyo
- p1074-1075
- Pawelec G et al. 1989. Stimulatory capacity of Workship T-cell antibodies on T-lymphocyte clones. Leukocyte Typing IV, Oxford Univeristy Press, Oxford, New York and Tokyo
- p310-311.2.
