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Anti-ATM [ATM 11G12]

Info

Catalogue Number 151333
Applications IF IP WB
Antigen/Gene or Protein Targets Ataxia Telangiesctasia Mutated (ATM)
Reactivity Human
Relevance The ATM protein is a member of the phosphatidylinositol-3 kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. It is thought that the activation of ATM by autophosphorylation might be the initiating event of cellular responses to irradiation. The classic form of ataxia telangiectasia, an autosomal recessive cerebellar ataxia, results from the presence of two truncating ATM mutations, leading to a total loss of the ATM protein.
Host Mouse
Immunogen Residues 992-1144 of ATM fusion protein
Subclass IgG1
Molecular Weight (kDa) 370
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Notes Suggested Dilution: 1:500
Research Area Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 5 entries

Tian et al. 2013. PLoS One. 8(9):e72303. PMID: 24023735.

WB

Reiman et al. 2011. Br J Cancer. 105(4):586-91. PMID: 21792198.

WB

Dutton et al. 2007. Blood. 109(6):2597-603. PMID: 17148591.

Clements et al. 2004. DNA Repair (Amst). 3(11):1493-502. PMID: 15380105.

IF

Starczynski et al. 2003. Am J Pathol. 163(2):423-32. PMID: 12875964.


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