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Anti-ATM [ATM 11G12]

Info

Catalogue Number 151333
Applications IF IP WB
Antigen/Gene or Protein Targets Ataxia Telangiesctasia Mutated (ATM)
Reactivity Human
Relevance The ATM protein is a member of the phosphatidylinositol-3 kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. It is thought that the activation of ATM by autophosphorylation might be the initiating event of cellular responses to irradiation. The classic form of ataxia telangiectasia, an autosomal recessive cerebellar ataxia, results from the presence of two truncating ATM mutations, leading to a total loss of the ATM protein.
Host Mouse
Immunogen Residues 992-1144 of ATM fusion protein
Subclass IgG1
Molecular Weight (kDa) 370
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Notes Suggested Dilution: 1:500
Research Area Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 10 entries

Dynamics of DNA damage induced pathways to cancer.

Europe PMC ID: 24023735

Tian et al. 2013. PLoS One. 8(9):e72303. PMID: 24023735.

WB

Reiman et al. 2011. Br J Cancer. 105(4):586-91. PMID: 21792198.

WB

Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours.

Europe PMC ID: 21792198

Dutton et al. 2007. Blood. 109(6):2597-603. PMID: 17148591.

Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells.

Europe PMC ID: 17148591

Clements et al. 2004. DNA Repair (Amst). 3(11):1493-502. PMID: 15380105.

IF

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.

Europe PMC ID: 15380105

Starczynski et al. 2003. Am J Pathol. 163(2):423-32. PMID: 12875964.

Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias.

Europe PMC ID: 12875964


Add a reference

References: 10 entries

Dynamics of DNA damage induced pathways to cancer.

Europe PMC ID: 24023735

Tian et al. 2013. PLoS One. 8(9):e72303. PMID: 24023735.

WB

Reiman et al. 2011. Br J Cancer. 105(4):586-91. PMID: 21792198.

WB

Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours.

Europe PMC ID: 21792198

Dutton et al. 2007. Blood. 109(6):2597-603. PMID: 17148591.

Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells.

Europe PMC ID: 17148591

Clements et al. 2004. DNA Repair (Amst). 3(11):1493-502. PMID: 15380105.

IF

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.

Europe PMC ID: 15380105

Starczynski et al. 2003. Am J Pathol. 163(2):423-32. PMID: 12875964.

Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias.

Europe PMC ID: 12875964


Add a reference

References: 10 entries

Dynamics of DNA damage induced pathways to cancer.

Tian et al. 2013. PLoS One. 8(9):e72303. PMID: 24023735.

WB

Reiman et al. 2011. Br J Cancer. 105(4):586-91. PMID: 21792198.

WB

Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours.

Dutton et al. 2007. Blood. 109(6):2597-603. PMID: 17148591.

Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells.

Clements et al. 2004. DNA Repair (Amst). 3(11):1493-502. PMID: 15380105.

IF

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.

Starczynski et al. 2003. Am J Pathol. 163(2):423-32. PMID: 12875964.

Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias.


Add a reference


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