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|Applications||IF IP WB|
|Antigen/Gene or Protein Targets||Ataxia Telangiesctasia Mutated (ATM)|
|Relevance||The ATM protein is a member of the phosphatidylinositol-3 kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. It is thought that the activation of ATM by autophosphorylation might be the initiating event of cellular responses to irradiation. The classic form of ataxia telangiectasia, an autosomal recessive cerebellar ataxia, results from the presence of two truncating ATM mutations, leading to a total loss of the ATM protein.|
|Immunogen||Residues 992-1144 of ATM fusion protein|
|Molecular Weight (kDa)||370|
|Recommended Growing Conditions||DMEM + 5% FCS|
|Notes||Suggested Dilution: 1:500|
|Research Area||Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling|
References: 5 entries
Tian et al. 2013. PLoS One. 8(9):e72303. PMID: 24023735.
Reiman et al. 2011. Br J Cancer. 105(4):586-91. PMID: 21792198.
Dutton et al. 2007. Blood. 109(6):2597-603. PMID: 17148591.
Clements et al. 2004. DNA Repair (Amst). 3(11):1493-502. PMID: 15380105.
Starczynski et al. 2003. Am J Pathol. 163(2):423-32. PMID: 12875964.
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