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Anti-Spastin [Sp 3G11/1]


Catalogue Number 151320
Applications ChIP ELISA IHC IF WB
Antigen/Gene or Protein Targets Spastin
Reactivity Human, Mouse and Rat
Relevance Spastin is thought have a role in microtubule dynamics through its function as a microtubule-severing protein. It is localised to the centrosome of neuronal cells but is not found in glial cells. Mutation in the ATPase binding domain of spastin causes hereditary spastic paraplegias (HSP), a large group of clinically similar disorders. Mutant forms of spastin are generally found throughout the cytoplasm rather then within the nucleus. There are two splice isoforms of spastin (one without exon4) and two alternative ATG start sites, which may determine the localisation of the translate protein.
Host Mouse
Immunogen Recombinant human spastin
Subclass IgG2a
Positive Control HeLa cell or rat brain extract
Molecular Weight (kDa) 52
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Suggested dilution for western blot: 1:500
Research Area Cardiovascular, Cell Cycle, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism, Neurobiology

References: 4 entries

Daftary et al. 2011. Mol Endocrinol. 25(9):1539-49. PMID: 21757506.

Lacroix et al. 2010. J Cell Biol. 189(6):945-54. PMID: 20530212.

Lacroix et al. 2010. J Cell Biol. 189(6):945-54. PMID: 20530212.


Salinas et al. 2005. J Neurochem. 95(5):1411-20. PMID: 16219033.

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