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Anti-Keratin18 [LDK18]


Catalogue Number 151317
Antigen/Gene or Protein Targets Keratin 18
Reactivity Human, Mouse and Pig
Relevance Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas.
Host Mouse
Immunogen Synthetic peptide of human keratin 18 (CSETNDTKVLRH-COOH)
Subclass IgG1
Positive Control Simple epithelial cells
Recommended Growing Conditions DMEM + 5% FCS
Notes Use LDK18 undiluted for indirect immunofluorescence assays and immunohistochemistry. This antibody is recommended for immunoblotting applications.
Research Area Cell Signaling & Signal Transduction

References: 2 entries

D'Alessandro et al. 2011. J Invest Dermatol. 131(7):1412-9. PMID: 21326298.

Hosoya et al. 2010. Anat Rec (Hoboken). 293(11):1864-72. PMID: 20818615.

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