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Anti-FIH [FIH162C]


Catalogue Number 151316
Applications IHC IF WB
Antigen/Gene or Protein Targets Factor Inhibiting HIF1 (FIH)
Reactivity Human
Relevance FIH, Factor Inhibiting HIF1 (Hypoxia-Inducible Factor), is an asparaginyl hydroxylase. FIH in conjunction with VHL represses HIF-1 transcriptional activity by disrupting the interaction of HIF-1 with the transcriptional coactivators CBP/p300, and by recruiting histone deacetylases. FIH activity is inhibited during hypoxia.
Host Mouse
Immunogen Full length human FIH expressed in Escherichia coli BL21(DE3) cells.
Subclass IgG1
Positive Control MCF7 cells
Molecular Weight (kDa) 40
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI + 10% FCS + 5% CO2
Strain Balb/c
Research Area Cancer, Epigenetics & Nuclear Signalling

References: 5 entries

Wollenick et al. 2012. Nucleic Acids Res. 40(5):1928-43. PMID: 22075993.

Yan et al. 2009. Br J Cancer. 101(7):1168-74. PMID: 19724277.

Cockman et al. 2006. Proc Natl Acad Sci U S A. 103(40):14767-72. PMID: 17003112.

Soilleux et al. 2005. Histopathology. 47(6):602-10. PMID: 16324198.

Stolze et al. 2004. J Biol Chem. 279(41):42719-25. PMID: 15302861.

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