Anti-TIGAR [9C10]
Invented at Cancer Research UK Glasgow: The Beatson Institute
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151312 |
| Applications | ChIP IP WB |
| Antigen/Gene or Protein Targets | TIGAR |
| Reactivity | Human |
| Relevance | TIGAR (TP53 induced glycolysis and apoptosis regulator) is a novel p53-inducible gene, that shows similarity to the bisphosphatase domain of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, the main regulator of glycolysis. TIGAR functions to lower fructose-2,6-bisphosphate levels in cells, resulting in an inhibition of glycolysis, and an overall decrease in intracellular reactive oxygen species (ROS) levels, correlating with a decreased sensitivity to apoptosis. |
| Host | Mouse |
| Immunogen | A 15-amino acid peptide corresponding to the exon COOH-terminal region of human TIGAR protein (CMNLQDHLNGLTETR). |
| Subclass | IgG2b |
| Molecular Weight (kDa) | 30 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 10% foetal Clone I (Hyclone cat no. SH30080.03) |
| Notes | Suggested dilution of 1:5000 |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, DNA Damage and Repair |
References: 2 entries
Bensaad et al. 2006. Cell. 126(1):107-20. PMID: 16839880.
TIGAR, a p53-inducible regulator of glycolysis and apoptosis.
Europe PMC ID: 16839880
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References: 2 entries
Bensaad et al. 2006. Cell. 126(1):107-20. PMID: 16839880.
TIGAR, a p53-inducible regulator of glycolysis and apoptosis.
Add a reference
