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Anti-TIGAR [9C10]


Catalogue Number 151312
Applications ChIP IP WB
Antigen/Gene or Protein Targets TIGAR
Reactivity Human
Relevance TIGAR (TP53 induced glycolysis and apoptosis regulator) is a novel p53-inducible gene, that shows similarity to the bisphosphatase domain of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, the main regulator of glycolysis. TIGAR functions to lower fructose-2,6-bisphosphate levels in cells, resulting in an inhibition of glycolysis, and an overall decrease in intracellular reactive oxygen species (ROS) levels, correlating with a decreased sensitivity to apoptosis.
Host Mouse
Immunogen A 15-amino acid peptide corresponding to the exon COOH-terminal region of human TIGAR protein (CMNLQDHLNGLTETR).
Subclass IgG2b
Molecular Weight (kDa) 30
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 10% foetal Clone I (Hyclone cat no. SH30080.03)
Notes Suggested dilution of 1:5000
Research Area Apoptosis and Programmed Cell Death, Cancer, DNA Damage and Repair

References: 1 entry

Bensaad et al. 2006. Cell. 126(1):107-20. PMID: 16839880.

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