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Anti-Phospho MDM2 (Ser186) [2G2 2.2]


Catalogue Number 151309
Applications WB
Antigen/Gene or Protein Targets Murine Double Minute 2 protein (MDM2), Phosphorylated (Serine 186)
Reactivity Human
Relevance MDM2's principal function is the ubiquitination and degradation of p53 tumour suppressor protein, promoting progression through the cell cycle and cell survival. MDM2 is over-expressed in many tumours. The phosphorylation of serines 166 and 186 is necessary for MDM2's translocation into the nucleus, thereby facilitating interaction with p53.
Host Mouse
Immunogen Peptide QRKRHKS(p)DSIS. S(p) represent a phosphorylated serine. This peptide represents the portion of MDM2 around Serine 186
Subclass IgG1
Positive Control Breast carcinoma
Molecular Weight (kDa) 90
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

References: 1 entry

Wei et al. 2013. Oncogene. 32(9):1110-20. PMID: 22525275.

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