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Anti-p53 [Pab DO-7]


Catalogue Number 151293
Antigen/Gene or Protein Targets p53 (N terminus)
Reactivity Human
Relevance p53 is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. p53 is involved in many mechanisms of anticancer function, and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. Understanding the functions of mutant p53 can help in the development of new therapeutic approaches that may be useful in a broad range of cancer types.
Host Mouse
Subclass IgG2b
Positive Control MDA-MB-231 cell line
Molecular Weight (kDa) 53
Recommended Growing Conditions DMEM + 5% FCS
Notes Immunocytochemistry (ICC) 1:20-1:200

Flow Cytometry (FACS) Assay Dependent

Immunofluorescence (IF) 1:20-1:200

Immunohistochemistry (Paraffin) (IHC (P)) 1:100 - 200

Immunoprecipitation (IP) 1:50-1:100

Western Blot (WB) 1:50-1:200
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 6 entries

İlhan et al. 2016. J Vet Diagn Invest. :. PMID: 27016721.

Tajima et al. 2015. Pathol Int. :. PMID: 25855894.

Ko et al. 2012. Pathol Int. 62(1):43-8. PMID: 22192803.

Molenaar et al. 2009. Proc Natl Acad Sci U S A. 106(31):12968-73. PMID: 19525400.

Stephen et al. 1995. J Mol Biol. 248(1):58-78. PMID: 7537340.

Vojtĕsek et al. 1992. J Immunol Methods. 151(1-2):237-44. PMID: 1378473.

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