Anti-Epithelial [LH39]
Invented by Prof Irene Leigh from Queen Mary University of London
Invented at Queen Mary University of London
- Datasheet
- References (19)
- Inventor Info
Info
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| Catalogue Number | 151287 |
| Applications | IHC IP WB |
| Antigen/Gene or Protein Targets | Epithelial cell marker |
| Reactivity | Primate |
| Relevance | LH39 is potentially useful in the study of benign and malignant human vascular disorders, diseases and tumours associated with angiogenesis, epithelial neoplasms, and conditions of tissue regeneration and repair, such as wound healing. |
| Host | Mouse |
| Immunogen | Cells from a single cell suspension of epidermal cells (obtained from fresh human neonatal foreskin) were lysed in Nonidet P40 in phosphate buffered saline and the insoluble pellet was sonicated to prepare insoluble fractions. |
| Positive Control | Cultured keratinocytes |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 185 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | LH39 precipitates a polypeptide of 185 kDa from cultured keratinocytes. |
| Research Area | Cancer, Cardiovascular, Cell Type or Organelle Marker |
References: 19 entries
Giehl et al. 2004. Br J Dermatol. 150(4):722-7. PMID: 15099369.
Alterations in the basement membrane zone in pili annulati hair follicles as demonstrated by electron microscopy and immunohistochemistry.
Europe PMC ID: 15099369
Passalidou et al. 2003. Br J Cancer. 88(4):553-9. PMID: 12592369.
Vascular patterns in reactive lymphoid tissue and in non-Hodgkin's lymphoma.
Europe PMC ID: 12592369
Passalidou et al. 2002. Br J Cancer. 86(2):244-9. PMID: 11870514.
Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas.
Europe PMC ID: 11870514
Kakolyris et al. 2001. Anticancer Res. 21(6B):4311-6. PMID: 11908685.
Assessment of vascular maturation in lung and breast carcinomas using a novel basement membrane component, LH39.
Europe PMC ID: 11908685
Kakolyris et al. 2000. Br J Cancer. 82(4):844-51. PMID: 10732757.
Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39.
Europe PMC ID: 10732757
Kakolyris et al. 1999. Cancer Res. 59(21):5602-7. PMID: 10554041.
Assessment of vascular maturation in non-small cell lung cancer using a novel basement membrane component, LH39: correlation with p53 and angiogenic factor expression.
Europe PMC ID: 10554041
Sinclair et al. 1994. Br J Dermatol. 131(4):499-505. PMID: 7524609.
The basement membrane zone of the nail.
Europe PMC ID: 7524609
McKay et al. 1994. Burns. 20 Suppl 1:S19-22. PMID: 8198736.
Reconstruction of human skin from glycerol-preserved allodermis and cultured keratinocyte sheets.
Europe PMC ID: 8198736
Almeida et al. 1992. J Pathol. 166(3):243-53. PMID: 1517880.
Almeida et al. 1992. J Pathol. 166(3):243-53. PMID: 1517880.
A novel lamina lucida component of epithelial and endothelial basement membranes detected by LH39 monoclonal antibody.
Europe PMC ID: 1517880
Add a reference
References: 19 entries
Giehl et al. 2004. Br J Dermatol. 150(4):722-7. PMID: 15099369.
Alterations in the basement membrane zone in pili annulati hair follicles as demonstrated by electron microscopy and immunohistochemistry.
Passalidou et al. 2003. Br J Cancer. 88(4):553-9. PMID: 12592369.
Vascular patterns in reactive lymphoid tissue and in non-Hodgkin's lymphoma.
Passalidou et al. 2002. Br J Cancer. 86(2):244-9. PMID: 11870514.
Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas.
Kakolyris et al. 2001. Anticancer Res. 21(6B):4311-6. PMID: 11908685.
Assessment of vascular maturation in lung and breast carcinomas using a novel basement membrane component, LH39.
Kakolyris et al. 2000. Br J Cancer. 82(4):844-51. PMID: 10732757.
Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39.
Kakolyris et al. 1999. Cancer Res. 59(21):5602-7. PMID: 10554041.
Assessment of vascular maturation in non-small cell lung cancer using a novel basement membrane component, LH39: correlation with p53 and angiogenic factor expression.
Sinclair et al. 1994. Br J Dermatol. 131(4):499-505. PMID: 7524609.
The basement membrane zone of the nail.
McKay et al. 1994. Burns. 20 Suppl 1:S19-22. PMID: 8198736.
Reconstruction of human skin from glycerol-preserved allodermis and cultured keratinocyte sheets.
Almeida et al. 1992. J Pathol. 166(3):243-53. PMID: 1517880.
Almeida et al. 1992. J Pathol. 166(3):243-53. PMID: 1517880.
A novel lamina lucida component of epithelial and endothelial basement membranes detected by LH39 monoclonal antibody.
Add a reference
