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Anti-Rad51C [Rad51C 2H11/6]


Catalogue Number 151286
Applications IHC IF IP WB
Antigen/Gene or Protein Targets Rad51C
Reactivity N/A
Relevance RAD51C is a Rad51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51C is also a component for the homologous recombination pathway.
Host Mouse
Immunogen Rad51C 2H11/6 was raised against His-tagged human Rad51C, overexpressed in e.coli and purified on a talon affinity column under denaturing conditions, followed by gel purification on a SDS-Page
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Rad51C 2H11/6 detects as little as 10ng of purified protein and also detects endogenouse hamster Rad51C in whole V79 cell extracts by western blotting.
Research Area DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 5 entries

Park et al. 2014. Oncogene. 33(40):4803-12. PMID: 24141787.

French et al. 2002. J Biol Chem. 277(22):19322-30. PMID: 11912211.

Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.

Masson et al. 2001. Proc Natl Acad Sci U S A. 98(15):8440-6. PMID: 11459987.

Dosanjh et al. 1998. Nucleic Acids Res. 26(5):1179-84. PMID: 9469824.

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