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Anti-Zebrafish DeltaD [zdd2]

Invented by Dr Gavin Wright at Wellcome Trust Sanger Institute

Info

Catalogue Number 151283
Applications ELISA FACS IHC IF WB
Antigen/Gene or Protein Targets Zebrafish DeltaD extracellular domain
Reactivity Zebrafish
Relevance Delta proteins activate Notch through a binding reaction that depends on their extracellular domains; they play a key role in the control of cell differentiation by lateral inhibition. DeltaD is widely expressed in subsets of cells in the nervous system, mesoderm, gut, and elsewhere. Deltas associate with membrane-associated scaffolding proteins MAGI1, MAGI2 and MAGI3. This antibody does not detect DeltaC; but it cross-reacts weakly with DeltaA.
Host Mouse
Immunogen Extracellular domain; DeltaD peptide
Subclass IgG1
Positive Control HEK293 cells transfected with deltaD; and zebrafish embryo
Myeloma Used Sp2/0-Ag14
Strain Balb/c
Notes Recommended for use in formalin fixed tissue sections of zebrafish.
Research Area Aquaculture, Cell Cycle, Developmental Biology, Neurobiology

References: 8 entries

Wright et al. 2011. Development. 138(14):2947-56. PMID: 21653612.

DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock.

Europe PMC ID: 21653612

Crosnier et al. 2005. Development. 132(5):1093-104. PMID: 15689380.

Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine.

Europe PMC ID: 15689380

Wright et al. 2004. Development. 131(22):5659-69. PMID: 15509766.

Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development.

Europe PMC ID: 15509766

Itoh et al. 2003. Dev Cell. 4(1):67-82. PMID: 12530964.

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.

Europe PMC ID: 12530964


Add a reference

References: 8 entries

Wright et al. 2011. Development. 138(14):2947-56. PMID: 21653612.

DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock.

Europe PMC ID: 21653612

Crosnier et al. 2005. Development. 132(5):1093-104. PMID: 15689380.

Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine.

Europe PMC ID: 15689380

Wright et al. 2004. Development. 131(22):5659-69. PMID: 15509766.

Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development.

Europe PMC ID: 15509766

Itoh et al. 2003. Dev Cell. 4(1):67-82. PMID: 12530964.

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.

Europe PMC ID: 12530964


Add a reference

References: 8 entries

Wright et al. 2011. Development. 138(14):2947-56. PMID: 21653612.

DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock.

Crosnier et al. 2005. Development. 132(5):1093-104. PMID: 15689380.

Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine.

Wright et al. 2004. Development. 131(22):5659-69. PMID: 15509766.

Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development.

Itoh et al. 2003. Dev Cell. 4(1):67-82. PMID: 12530964.

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.


Add a reference


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