Anti-XRCC2 [XRCC2 1G4/1]
Invented by Dr Stephen West from Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151282 |
| Applications | WB |
| Antigen/Gene or Protein Targets | XRay Repair Cross Complementing 2 (XRCC2) |
| Reactivity | Human and Hamster |
| Relevance | X-Ray Repair Cross Complementing 2 (XRCC2) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC2 is also a component of the homologous recombination pathway. |
| Host | Mouse |
| Positive Control | HeLa nuclear extracts |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 33 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | XRCC2 1G4/1 does not recognise other paralogs. |
| Research Area | Bacteriology, DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 6 entries
Gildemeister et al. 2009. J Biol Chem. 284(46):31945-52. PMID: 19783859.
Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C.
Europe PMC ID: 19783859
Nagaraju et al. 2009. Mol Cell Biol. 29(15):4283-94. PMID: 19470754.
XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids.
Europe PMC ID: 19470754
French et al. 2002. J Biol Chem. 277(22):19322-30. PMID: 11912211.
Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability.
Europe PMC ID: 11912211
Add a reference
References: 6 entries
Gildemeister et al. 2009. J Biol Chem. 284(46):31945-52. PMID: 19783859.
Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C.
Nagaraju et al. 2009. Mol Cell Biol. 29(15):4283-94. PMID: 19470754.
XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids.
French et al. 2002. J Biol Chem. 277(22):19322-30. PMID: 11912211.
Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability.
Add a reference
