Anti-CyclinA [AT10.2]
Invented by Julian Gannon from The Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151261 |
| Applications | IHC IP WB |
| Antigen/Gene or Protein Targets | Cyclin A |
| Synonyms | CCNA1; Cyclin A1; Testicular Tissue Protein Li 34; CT146 |
| Reactivity | Human |
| Relevance | Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase. E23.1 is extremely sensitive for immunoblotting Cyclin A. |
| Host | Mouse |
| Immunogen | Recombinant Human Cyclin A |
| Subclass | IgG1 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM +10% FCS |
| Strain | Balb/c |
| Notes |
Immunohistochemistry 1:10-1:2000 Immunohistochemistry-Frozen 1:10-1:2000 Immunohistochemistry-Paraffin 1:10-1:2000 Immunoprecipitation 1:10-1:500 |
| Research Area | Cancer, Cell Cycle, Epigenetics & Nuclear Signalling |
References: 4 entries
Geley et al. 2001. J Cell Biol. 153(1):137-48. PMID: 11285280.
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.
Europe PMC ID: 11285280
Adamczewski et al. 1993. J Virol. 67(11):6551-7. PMID: 8411358.
Simian virus 40 large T antigen associates with cyclin A and p33cdk2.
Europe PMC ID: 8411358
Add a reference
References: 4 entries
Geley et al. 2001. J Cell Biol. 153(1):137-48. PMID: 11285280.
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.
Adamczewski et al. 1993. J Virol. 67(11):6551-7. PMID: 8411358.
Simian virus 40 large T antigen associates with cyclin A and p33cdk2.
Add a reference
