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Anti-CyclinA [AT10.2]

Invented by Julian Gannon at The Francis Crick Institute

Info

Catalogue Number 151261
Applications IHC IP WB
Antigen/Gene or Protein Targets Cyclin A
Synonyms CCNA1; Cyclin A1; Testicular Tissue Protein Li 34; CT146
Reactivity Human
Relevance Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase. E23.1 is extremely sensitive for immunoblotting Cyclin A.
Host Mouse
Immunogen Recombinant Human Cyclin A
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM +10% FCS
Strain Balb/c
Notes Immunohistochemistry 1:10-1:2000

Immunohistochemistry-Frozen 1:10-1:2000

Immunohistochemistry-Paraffin 1:10-1:2000

Immunoprecipitation 1:10-1:500
Research Area Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

References: 4 entries

Geley et al. 2001. J Cell Biol. 153(1):137-48. PMID: 11285280.

Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.

Europe PMC ID: 11285280

Adamczewski et al. 1993. J Virol. 67(11):6551-7. PMID: 8411358.

Simian virus 40 large T antigen associates with cyclin A and p33cdk2.

Europe PMC ID: 8411358


Add a reference

References: 4 entries

Geley et al. 2001. J Cell Biol. 153(1):137-48. PMID: 11285280.

Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.

Europe PMC ID: 11285280

Adamczewski et al. 1993. J Virol. 67(11):6551-7. PMID: 8411358.

Simian virus 40 large T antigen associates with cyclin A and p33cdk2.

Europe PMC ID: 8411358


Add a reference

References: 4 entries

Geley et al. 2001. J Cell Biol. 153(1):137-48. PMID: 11285280.

Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.

Adamczewski et al. 1993. J Virol. 67(11):6551-7. PMID: 8411358.

Simian virus 40 large T antigen associates with cyclin A and p33cdk2.


Add a reference


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