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Anti-Cul1 [AS97.1]

Invented by Julian Gannon at The Francis Crick Institute

Info

Catalogue Number 151253
Applications IP WB
Antigen/Gene or Protein Targets Cullin 1 (Cul1)
Reactivity Human and Mouse
Relevance Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle.
Host Mouse
Immunogen Bacterially expressed full length recombinant human culllin 1. (Cul1)
Subclass IgG2a
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 10% FCS
Notes Recommended concentration: 2.5ug/ml
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle

References: 4 entries

Mao et al. 2011. J Biol Chem. 286(37):32355-65. PMID: 21778237.

COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.

Europe PMC ID: 21778237

Alao et al. 2004. Clin Cancer Res. 10(23):8094-104. PMID: 15585645.

Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.

Europe PMC ID: 15585645


Add a reference

References: 4 entries

Mao et al. 2011. J Biol Chem. 286(37):32355-65. PMID: 21778237.

COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.

Europe PMC ID: 21778237

Alao et al. 2004. Clin Cancer Res. 10(23):8094-104. PMID: 15585645.

Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.

Europe PMC ID: 15585645


Add a reference

References: 4 entries

Mao et al. 2011. J Biol Chem. 286(37):32355-65. PMID: 21778237.

COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.

Alao et al. 2004. Clin Cancer Res. 10(23):8094-104. PMID: 15585645.

Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.


Add a reference


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