Cancer Research Technology
Log in Register
Menu

Anti-Cdk2 [AN21.2]

Invented by Julian Gannon at The Francis Crick Institute

Info

Catalogue Number 151245
Applications ELISA WB
Antigen/Gene or Protein Targets Cyclin-dependent kinase 2 (cdk2)
Synonyms Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2; P33 Protein Kinase; CDKN2; CDC2-Related Protein Kinase; P33(CDK2)
Reactivity Human, Mouse and Xenopus laevis
Relevance Cdk2 is a cell cycle protein closely related to Cdk1 (Cdc2) and a useful marker of proliferation. Cdk2 binds cyclins A and E and controls progression into S-phase. AN21.2 is useful as a general CDK antibody since it reacts with both Cdk1 and Cdk2.
Host Mouse
Immunogen Human recombinant Cdk2
Subclass IgG2a
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 10% FCS
Notes Recommended concentration for western blot: 2.5ug/ml. The antibody cross reacts with Cdk1.
Research Area Cancer, Cell Cycle, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling

References: 4 entries

Lee et al. 2012. Evid Based Complement Alternat Med. 2012:702857. PMID: 22701509.

Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway.

Europe PMC ID: 22701509

Huang et al. 2008. Cell Cycle. 7(18):2846-55. PMID: 18769144.

ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage.

Europe PMC ID: 18769144


Add a reference

References: 4 entries

Lee et al. 2012. Evid Based Complement Alternat Med. 2012:702857. PMID: 22701509.

Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway.

Europe PMC ID: 22701509

Huang et al. 2008. Cell Cycle. 7(18):2846-55. PMID: 18769144.

ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage.

Europe PMC ID: 18769144


Add a reference

References: 4 entries

Lee et al. 2012. Evid Based Complement Alternat Med. 2012:702857. PMID: 22701509.

Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway.

Huang et al. 2008. Cell Cycle. 7(18):2846-55. PMID: 18769144.

ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage.


Add a reference


This reagent does not have any reviews at the moment.