Anti-Cdk2 [AN21.2]
Invented by Julian Gannon from The Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151245 |
| Applications | ELISA WB |
| Antigen/Gene or Protein Targets | Cyclin-dependent kinase 2 (cdk2) |
| Synonyms | Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2; P33 Protein Kinase; CDKN2; CDC2-Related Protein Kinase; P33(CDK2) |
| Reactivity | Human, Mouse and Xenopus laevis |
| Relevance | Cdk2 is a cell cycle protein closely related to Cdk1 (Cdc2) and a useful marker of proliferation. Cdk2 binds cyclins A and E and controls progression into S-phase. AN21.2 is useful as a general CDK antibody since it reacts with both Cdk1 and Cdk2. |
| Host | Mouse |
| Immunogen | Human recombinant Cdk2 |
| Subclass | IgG2a |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 10% FCS |
| Notes | Recommended concentration for western blot: 2.5ug/ml. The antibody cross reacts with Cdk1. |
| Research Area | Cancer, Cell Cycle, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling |
References: 4 entries
Lee et al. 2012. Evid Based Complement Alternat Med. 2012:702857. PMID: 22701509.
Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway.
Europe PMC ID: 22701509
Huang et al. 2008. Cell Cycle. 7(18):2846-55. PMID: 18769144.
ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage.
Europe PMC ID: 18769144
Add a reference
References: 4 entries
Lee et al. 2012. Evid Based Complement Alternat Med. 2012:702857. PMID: 22701509.
Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway.
Huang et al. 2008. Cell Cycle. 7(18):2846-55. PMID: 18769144.
ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage.
Add a reference
