Anti-PDECGF [PGF 44C]
Invented by Prof Roy Bicknell from University Of Birmingham
Invented at University of Oxford
- Datasheet
- References (12)
- Inventor Info
Info
| Catalogue Number | 151220 |
| Applications | IHC IF IP WB |
| Antigen/Gene or Protein Targets | Platelet-derived endothelial cell growth factor (thymidine phosphorylase); PD-ECGF. |
| Reactivity | Human |
| Relevance | PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours. |
| Host | Mouse |
| Immunogen | Full length human protein in E. coli |
| Positive Control | HUVEC cell or breast carcinoma |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 55 (reduced) |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes | PGF 44C blocks enzyme activity. |
| Research Area | Cancer, Cardiovascular, Immunology |
References: 12 entries
Weng et al. 2012. Basic Clin Pharmacol Toxicol. 110(3):298-306. PMID: 21973306.
Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression.
Europe PMC ID: 21973306
Ko et al. 2011. J Pharmacol Exp Ther. 338(1):184-94. PMID: 21444628.
Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells.
Europe PMC ID: 21444628
Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.
DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.
Europe PMC ID: 12754744
Fox et al. 1997. Ann Oncol. 8(3):271-5. PMID: 9137797.
Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF.
Europe PMC ID: 9137797
Fox et al. 1995. J Pathol. 176(2):183-90. PMID: 7636628.
Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.
Europe PMC ID: 7636628
Moghaddam et al. 1995. Proc Natl Acad Sci U S A. 92(4):998-1002. PMID: 7532308.
Thymidine phosphorylase is angiogenic and promotes tumor growth.
Europe PMC ID: 7532308
Add a reference
References: 12 entries
Weng et al. 2012. Basic Clin Pharmacol Toxicol. 110(3):298-306. PMID: 21973306.
Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression.
Ko et al. 2011. J Pharmacol Exp Ther. 338(1):184-94. PMID: 21444628.
Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells.
Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.
DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.
Fox et al. 1997. Ann Oncol. 8(3):271-5. PMID: 9137797.
Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF.
Fox et al. 1995. J Pathol. 176(2):183-90. PMID: 7636628.
Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.
Moghaddam et al. 1995. Proc Natl Acad Sci U S A. 92(4):998-1002. PMID: 7532308.
Thymidine phosphorylase is angiogenic and promotes tumor growth.
Add a reference
