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Anti-PDECGF [PGF 44C]

Invented by Prof Roy Bicknell at University Of Birmingham

Info

Catalogue Number 151220
Applications IHC IF IP WB
Antigen/Gene or Protein Targets Platelet-derived endothelial cell growth factor (thymidine phosphorylase); PD-ECGF.
Reactivity Human
Relevance PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours.
Host Mouse
Immunogen Full length human protein in E. coli
Subclass IgG1
Positive Control HUVEC cell or breast carcinoma
Molecular Weight (kDa) 55 (reduced)
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Notes PGF 44C blocks enzyme activity.
Research Area Cancer, Cardiovascular, Immunology

References: 12 entries

Weng et al. 2012. Basic Clin Pharmacol Toxicol. 110(3):298-306. PMID: 21973306.

Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression.

Europe PMC ID: 21973306

Ko et al. 2011. J Pharmacol Exp Ther. 338(1):184-94. PMID: 21444628.

Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells.

Europe PMC ID: 21444628

Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.

Europe PMC ID: 12754744

Fox et al. 1997. Ann Oncol. 8(3):271-5. PMID: 9137797.

Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF.

Europe PMC ID: 9137797

Fox et al. 1995. J Pathol. 176(2):183-90. PMID: 7636628.

Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.

Europe PMC ID: 7636628

Moghaddam et al. 1995. Proc Natl Acad Sci U S A. 92(4):998-1002. PMID: 7532308.

Thymidine phosphorylase is angiogenic and promotes tumor growth.

Europe PMC ID: 7532308


Add a reference

References: 12 entries

Weng et al. 2012. Basic Clin Pharmacol Toxicol. 110(3):298-306. PMID: 21973306.

Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression.

Europe PMC ID: 21973306

Ko et al. 2011. J Pharmacol Exp Ther. 338(1):184-94. PMID: 21444628.

Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells.

Europe PMC ID: 21444628

Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.

Europe PMC ID: 12754744

Fox et al. 1997. Ann Oncol. 8(3):271-5. PMID: 9137797.

Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF.

Europe PMC ID: 9137797

Fox et al. 1995. J Pathol. 176(2):183-90. PMID: 7636628.

Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.

Europe PMC ID: 7636628

Moghaddam et al. 1995. Proc Natl Acad Sci U S A. 92(4):998-1002. PMID: 7532308.

Thymidine phosphorylase is angiogenic and promotes tumor growth.

Europe PMC ID: 7532308


Add a reference

References: 12 entries

Weng et al. 2012. Basic Clin Pharmacol Toxicol. 110(3):298-306. PMID: 21973306.

Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression.

Ko et al. 2011. J Pharmacol Exp Ther. 338(1):184-94. PMID: 21444628.

Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells.

Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.

Fox et al. 1997. Ann Oncol. 8(3):271-5. PMID: 9137797.

Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF.

Fox et al. 1995. J Pathol. 176(2):183-90. PMID: 7636628.

Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.

Moghaddam et al. 1995. Proc Natl Acad Sci U S A. 92(4):998-1002. PMID: 7532308.

Thymidine phosphorylase is angiogenic and promotes tumor growth.


Add a reference


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