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Anti-SIGLEC3 [CD33 3D6]


Catalogue Number 151219
Applications ELISA
Antigen/Gene or Protein Targets SIGLEC3 (CD33)
Synonyms Sialic Acid Binding Ig Like Lectin 12; SIGLECL1; SLG 3; Siglec-12; Siglec-L1; S2V
Reactivity Human
Relevance The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. CD33 is found on granulocyte and macrophage precursors in the bone marrow, but not on pluripotent stem cells. CD33 is also expressed on, and a useful marker for, peripheral monocytes. CD33 is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias.
Host Mouse
Immunogen CD33-Fc recombinant protein
Subclass IgG1
Positive Control CD33 transfected COS cells
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Research Area Cancer, Cell Type or Organelle Marker, Immunology, Stem Cell Biology

References: 2 entries

Taylor et al. 1999. J Biol Chem. 274(17):11505-12. PMID: 10206955.

Freeman et al. 1995. Blood. 85(8):2005-12. PMID: 7718872.

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