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Anti-MUC18 [OJ79c MUC 18]


Catalogue Number 151214
Applications FACS IHC IF
Antigen/Gene or Protein Targets MUC18 (CD146)
Synonyms ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
Reactivity Human
Relevance CD146 has been identified as a cell adhesion molecule and is useful in differential diagnosis of certain lesions including melanomas and various types of gestational trophoblastic lesions. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
Host Mouse
Immunogen Recombinant MUC18 (D1-D5) Fc chimeric protein
Subclass IgG1 kappa
Positive Control A-375 cell, SK-MEL-24 cell, HUV-EC or HeLa cell lysates. Tonsil or Melanoma.
Molecular Weight (kDa) 130kDa
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions RPMI + 10% FCS + HAT
Notes Cellular Localization: Cell surface
Suggested Dilutions: Flow Cytometry (0.5-1ug/million cells); Immunofluorescence (0.5-1.0ug/ml);
Research Area Adhesion, Cancer, Cardiovascular, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References: 5 entries

Smith et al. 2011. Immunology. 132(2):256-65. PMID: 21039468.

Iohara et al. 2008. Stem Cells. 26(9):2408-18. PMID: 18583536.

Crisan et al. 2008. Cell Stem Cell. 3(3):301-13. PMID: 18786417.

Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935.

Kuzu et al. 1993. Lab Invest. 69(3):322-8. PMID: 7690867.

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