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Anti-Cytochrome P450 1A2 [D15]


Catalogue Number 151201
Applications ELISA IHC IF WB
Antigen/Gene or Protein Targets Cytochrome P450 1A2, CYP1A2
Reactivity Human, Mouse and Rat
Relevance In animals, P450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolising enzymes in humans.
Host Mouse
Immunogen MC1a (Preparation C31B4, rat liver cytochrome P4501A2)
Subclass IgG1
Positive Control MCF7 cells (IF) or human normal liver (IHC)
Molecular Weight (kDa) 52
Recommended Growing Conditions DMEM + 5% FCS.
Notes D15 cross reacts with CYP1A1 & CYP1A2.
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism

References: 3 entries

Getachew et al. 2010. Biochem Pharmacol. 79(9):1363-71. PMID: 20036646.

Seibert et al. 2009. J Proteome Res. 8(4):1672-81. PMID: 19714871.

Lane et al. 2007. Mol Cell Proteomics. 6(6):953-62. PMID: 17296599.

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