Anti-Cytochrome P450 1A2 [D15]
Invented by Prof Roland Wolf from University of Dundee
Invented at University of Dundee
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151201 |
| Applications | ELISA IHC IF WB |
| Antigen/Gene or Protein Targets | Cytochrome P450 1A2, CYP1A2 |
| Reactivity | Human, Mouse and Rat |
| Relevance | In animals, P450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolising enzymes in humans. |
| Host | Mouse |
| Immunogen | MC1a (Preparation C31B4, rat liver cytochrome P4501A2) |
| Positive Control | MCF7 cells (IF) or human normal liver (IHC) |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 52 |
| Recommended Growing Conditions | DMEM + 5% FCS. |
| Notes |
D15 cross reacts with CYP1A1 & CYP1A2. This reagent was created through a research collaboration between Cancer Research UK and Syngenta Crop Protection AG. |
| Research Area | Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism |
References: 6 entries
Getachew et al. 2010. Biochem Pharmacol. 79(9):1363-71. PMID: 20036646.
Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice.
Europe PMC ID: 20036646
Seibert et al. 2009. J Proteome Res. 8(4):1672-81. PMID: 19714871.
Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry.
Europe PMC ID: 19714871
Lane et al. 2007. Mol Cell Proteomics. 6(6):953-62. PMID: 17296599.
Comparative cytochrome P450 proteomics in the livers of immunodeficient mice using 18O stable isotope labeling.
Europe PMC ID: 17296599
Add a reference
References: 6 entries
Getachew et al. 2010. Biochem Pharmacol. 79(9):1363-71. PMID: 20036646.
Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice.
Seibert et al. 2009. J Proteome Res. 8(4):1672-81. PMID: 19714871.
Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry.
Lane et al. 2007. Mol Cell Proteomics. 6(6):953-62. PMID: 17296599.
Comparative cytochrome P450 proteomics in the livers of immunodeficient mice using 18O stable isotope labeling.
Add a reference
Inventor Information
Inventors
|
Prof Roland Wolf |
