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Anti-p21 [AC8.3]


Catalogue Number 151194
Antigen/Gene or Protein Targets p21
Synonyms Cyclin-Dependent Kinase Inhibitor 1A; CDK-Interacting Protein 1; CDKN1; CAP20; MDA-6; CIP1; SDI1; WAF1; P21; Melanoma Differentiation Associated Protein 6; Wild-Type P53-Activated Fragment 1; CDK-Interaction Protein 1; DNA Synthesis Inhibitor; P21CIP1; MDA6; PIC1
Reactivity Human
Relevance Cell cycle progression is regulated by cyclins and their cognate Cdks. p21 (WAF1/CIP1) inhibits the activity of each member of the cyclin/Cdk family, and overexpression of this protein inhibits the proliferation of mammalian cells. The expression of p21 is inducible by a wide range of stress stimuli. p21 is tightly regulated at the transcriptional level by p53, and probably serves as the effector of p53 cell cycle control. AC8.3 can be used as a detection system for rapidly dividing cells and is recommended for use in tissue culture.
Host Mouse
Immunogen His-tagged human p21 expressed in bacleva virus.
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Research Area Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 2 entries

Xu et al. 2010. Biol Pharm Bull. 33(5):743-51. PMID: 20460749.

Petrides et al. 2008. J Comp Neurol. 507(5):1653-62. PMID: 18241050.

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