Anti-p21 [AC8.3]
Invented by Julian Gannon from The Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151194 |
| Applications | ELISA FACS IHC IF IP WB |
| Antigen/Gene or Protein Targets | p21 |
| Synonyms | Cyclin-Dependent Kinase Inhibitor 1A; CDK-Interacting Protein 1; CDKN1; CAP20; MDA-6; CIP1; SDI1; WAF1; P21; Melanoma Differentiation Associated Protein 6; Wild-Type P53-Activated Fragment 1; CDK-Interaction Protein 1; DNA Synthesis Inhibitor; P21CIP1; MDA6; PIC1 |
| Reactivity | Human |
| Relevance | Cell cycle progression is regulated by cyclins and their cognate Cdks. p21 (WAF1/CIP1) inhibits the activity of each member of the cyclin/Cdk family, and overexpression of this protein inhibits the proliferation of mammalian cells. The expression of p21 is inducible by a wide range of stress stimuli. p21 is tightly regulated at the transcriptional level by p53, and probably serves as the effector of p53 cell cycle control. AC8.3 can be used as a detection system for rapidly dividing cells and is recommended for use in tissue culture. |
| Host | Mouse |
| Immunogen | His-tagged human p21 expressed in bacleva virus. |
| Subclass | IgG1 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Research Area | Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 4 entries
Xu et al. 2010. Biol Pharm Bull. 33(5):743-51. PMID: 20460749.
Targeting the Na(+)/K(+)-ATPase alpha1 subunit of hepatoma HepG2 cell line to induce apoptosis and cell cycle arresting.
Europe PMC ID: 20460749
Petrides et al. 2008. J Comp Neurol. 507(5):1653-62. PMID: 18241050.
Differential output of the high-sensitivity rod photoreceptor: AII amacrine pathway.
Europe PMC ID: 18241050
Add a reference
References: 4 entries
Xu et al. 2010. Biol Pharm Bull. 33(5):743-51. PMID: 20460749.
Targeting the Na(+)/K(+)-ATPase alpha1 subunit of hepatoma HepG2 cell line to induce apoptosis and cell cycle arresting.
Petrides et al. 2008. J Comp Neurol. 507(5):1653-62. PMID: 18241050.
Differential output of the high-sensitivity rod photoreceptor: AII amacrine pathway.
Add a reference
