Anti-Rab11a [STo 7C10]
Invented by Dr Sharon Tooze from The Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
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Info
| Catalogue Number | 151192 |
| Applications | ELISA IP WB |
| Antigen/Gene or Protein Targets | Rab11a |
| Reactivity | Human |
| Relevance | Rab11a is a member of the Rab family of Ras-like small GTPases, which regulate membrane trafficking events (e.g. vesicle recycling). Regulates endocytic recycling, may exert its functions by interacting with multiple effector proteins in different complexes & acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. |
| Host | Mouse |
| Immunogen | Rab11a peptide KQMSDRRENDM |
| Subclass | IgG1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes | Peptide immunogen has 100% sequence similarity with mouse homolog. |
| Research Area | Cancer, Cell Signaling & Signal Transduction |
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